Organic Solvent and Surfactant Free Fluorescent Organic Nanoparticles by Laser Ablation of Aggregation-Induced Enhanced Emission Dyes

Chang Keun Lim, Anton A. Popov, Gleb Tselikov, Jeongyun Heo, Artem Pliss, Sehoon Kim, Andrei V. Kabashin, Paras N. Prasad

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Less toxic and highly fluorescent nanoparticles are in high demand to image biological events and early-stage disease. A strategy to fabricate highly fluorescent organic nanoparticles by laser ablation of aggregation-induced enhanced emission (AIE) luminophores, which are free of any organic solvent and surfactant, is presented. As these dyes provide no concentration quenching, the increased number of photoluminescent molecules in a nanoparticle produces bright fluorescence even with their small size (<2 nm), making them highly suitable for intracellular uptake and imaging for a variety of biomedical applications. The design and synthesis of a new AIE luminophore, DCEtDCS, are reported and its photoluminescent quantum yield enhancement up to 58% in the aggregated state is demonstrated. Extremely stable nanoparticles of this luminophore with a narrow size distribution, by laser ablation in water are reported and its superior optical properties that are comparable to quantum dots are verified. The highly negative surface charge of these nanoparticles impedes cellular uptake, but when the surface is coated with chitosan, a cationic polymer, intracellular uptake in microglia is achieved. The strategy provides a novel tool to produce in water, ultrasmall and surfactant-free highly fluorescent organic nanoparticles suitable for biomedical applications.

Original languageEnglish
Article number1800164
JournalAdvanced Optical Materials
Volume6
Issue number16
DOIs
Publication statusPublished - 2018 Aug 20
Externally publishedYes

Fingerprint

Laser ablation
Surface-Active Agents
Organic solvents
laser ablation
Surface active agents
Coloring Agents
Agglomeration
Dyes
dyes
surfactants
Nanoparticles
nanoparticles
Water
Poisons
Chitosan
Quantum yield
Surface charge
water
Semiconductor quantum dots
Quenching

Keywords

  • aggregation-induced (enhanced) emission
  • cellular imaging
  • fluorescent organic nanoparticles
  • laser ablation
  • toxicity

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Organic Solvent and Surfactant Free Fluorescent Organic Nanoparticles by Laser Ablation of Aggregation-Induced Enhanced Emission Dyes. / Lim, Chang Keun; Popov, Anton A.; Tselikov, Gleb; Heo, Jeongyun; Pliss, Artem; Kim, Sehoon; Kabashin, Andrei V.; Prasad, Paras N.

In: Advanced Optical Materials, Vol. 6, No. 16, 1800164, 20.08.2018.

Research output: Contribution to journalArticle

Lim, Chang Keun ; Popov, Anton A. ; Tselikov, Gleb ; Heo, Jeongyun ; Pliss, Artem ; Kim, Sehoon ; Kabashin, Andrei V. ; Prasad, Paras N. / Organic Solvent and Surfactant Free Fluorescent Organic Nanoparticles by Laser Ablation of Aggregation-Induced Enhanced Emission Dyes. In: Advanced Optical Materials. 2018 ; Vol. 6, No. 16.
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