Organically modified silica nanoparticles with intraparticle heavy-atom effect on the encapsulated photosensitizer for enhanced efficacy of photodynamic therapy

Sehoon Kim, Tymish Y. Ohulchanskyy, Dhruba Bharali, Yihui Chen, Ravindra K. Pandey, Paras N. Prasad

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

We report a novel nanoassembly formulation for photodynamic therapy, which is composed of covalently iodine-concentrated organically modified silica (ORMOSIL) nanoparticles (diameter < 30 nm) and a hydrophobic photosensitizer embedded therein. Comparative studies with iodinated and noniodinated nanoparticles have demonstrated that the intraparticle external heavy-atom effect on the encapsulated photosensitizer molecules significantly enhances the efficiency of 1O 2 generation and, thereby, the in vitro PDT efficacy.

Original languageEnglish
Pages (from-to)12641-12644
Number of pages4
JournalJournal of Physical Chemistry C
Volume113
Issue number29
DOIs
Publication statusPublished - 2009 Jul 23
Externally publishedYes

Fingerprint

Photodynamic therapy
Photosensitizing Agents
Photosensitizers
Silicon Dioxide
therapy
Silica
Nanoparticles
silicon dioxide
Atoms
nanoparticles
Iodine
iodine
atoms
formulations
Molecules
molecules
1-phenyl-3,3-dimethyltriazene

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Energy(all)
  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films

Cite this

Organically modified silica nanoparticles with intraparticle heavy-atom effect on the encapsulated photosensitizer for enhanced efficacy of photodynamic therapy. / Kim, Sehoon; Ohulchanskyy, Tymish Y.; Bharali, Dhruba; Chen, Yihui; Pandey, Ravindra K.; Prasad, Paras N.

In: Journal of Physical Chemistry C, Vol. 113, No. 29, 23.07.2009, p. 12641-12644.

Research output: Contribution to journalArticle

Kim, Sehoon ; Ohulchanskyy, Tymish Y. ; Bharali, Dhruba ; Chen, Yihui ; Pandey, Ravindra K. ; Prasad, Paras N. / Organically modified silica nanoparticles with intraparticle heavy-atom effect on the encapsulated photosensitizer for enhanced efficacy of photodynamic therapy. In: Journal of Physical Chemistry C. 2009 ; Vol. 113, No. 29. pp. 12641-12644.
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