Organically modified silica nanoparticles with intraparticle heavy-atom effect on the encapsulated photosensitizer for enhanced efficacy of photodynamic therapy

Sehoon Kim, Tymish Y. Ohulchanskyy, Dhruba Bharali, Yihui Chen, Ravindra K. Pandey, Paras N. Prasad

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65 Citations (Scopus)


We report a novel nanoassembly formulation for photodynamic therapy, which is composed of covalently iodine-concentrated organically modified silica (ORMOSIL) nanoparticles (diameter < 30 nm) and a hydrophobic photosensitizer embedded therein. Comparative studies with iodinated and noniodinated nanoparticles have demonstrated that the intraparticle external heavy-atom effect on the encapsulated photosensitizer molecules significantly enhances the efficiency of 1O 2 generation and, thereby, the in vitro PDT efficacy.

Original languageEnglish
Pages (from-to)12641-12644
Number of pages4
JournalJournal of Physical Chemistry C
Issue number29
Publication statusPublished - 2009 Jul 23
Externally publishedYes


ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Energy(all)
  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films

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