Organizing pneumonia associated with oxaliplatin-combined chemotherapy: A case report

Eun Joo Lee, Sang Yeub Lee, Kwang Ho In, Chul Hwan Kim, Sanghoon Park

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    Objective: To report a case of oxaliplatin-combined chemotherapy-induced interstitial lung disease. Clinical Presentation and Intervention: A 57-year-old man was referred complaining of dyspnea and fever after treatment with an oxaliplatin-combined chemotherapeutic agent for metastatic colorectal cancer. Fever development and spontaneous subsidence were observed during the chemotherapeutic course repeatedly until the 9th cycle. A computer-tomographic (CT) scan revealed bilateral, peripherally distributed, patchy consolidation suggestive of an interstitial lung disease. As a confirmative step, video-assisted thoracoscopic surgical biopsy was attempted; the characteristic intraluminal organizing fibrous plug in the bronchioles and alveoli was seen. Corticosteroid therapy was administered, which rapidly improved the patient's symptoms and chest CT findings. Conclusion: This case showed that oxaliplatin may be implicated in the etiology of interstitial lung disease, since withdrawal of the drug resulted in improvement of interstitial lung disease.

    Original languageEnglish
    Pages (from-to)89-92
    Number of pages4
    JournalMedical Principles and Practice
    Volume21
    Issue number1
    DOIs
    Publication statusPublished - 2011 Dec

    Keywords

    • Interstitial pneumonia
    • Organizing pneumonia
    • Oxaliplatin
    • Pulmonary toxicity

    ASJC Scopus subject areas

    • Medicine(all)

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