Organocatalytic asymmetric michael addition of ketones to α, β-unsaturated nitro compounds

Jae Ho Shim, Si Hun Nam, Byeong Seon Kim, Deok Chan Ha

Research output: Contribution to journalArticle

Abstract

An organic catalyst “(R, R)-1,2-diphenylethylenediamine(DPEN) derivative” was devel-oped as a chiral bifunctional organocatalyst and applied for asymmetric Michael additions of aromatic ketones to trans-β-nitroalkene compounds under neutral conditions. The isopropyl-subs-tituted thiourea catalyst in neutral condition provides high chemical yield and enantioselectivities (ee) (up to 96% yield, 98% ee).

Original languageEnglish
Article number618
JournalCatalysts
Volume10
Issue number6
DOIs
Publication statusPublished - 2020 Jun

Keywords

  • Asymmetric
  • Enantioselectivity
  • Organocatalyst
  • Thiourea catalyst
  • Yield

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry

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