Origami-paper-based device for microvesicle/exosome preconcentration and isolation

Hyerin Kim; Kyu Hyoung Lee; Sung Il Han; Dongho Lee; Seok Chung; Dohwan Lee; Jeong Hoon Lee

doi:10.1039/c9lc00796b

Origami-paper-based device for microvesicle/exosome preconcentration and isolation

Hyerin Kim, Kyu Hyoung Lee, Sung Il Han, Dongho Lee, Seok Chung, Dohwan Lee, Jeong Hoon Lee

School of Mechanical Engineering

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

Microvesicles and exosomes are promising liquid biopsy biomarkers. However, conventional isolation techniques damage and contaminate the biomarkers. We developed an origami-paper-based device for effective isolation of biomarkers with less damage and in fewer steps. The multi-folded device enables the preconcentration of the microvesicles/exosomes on specific layers (∼5-fold) by the ion concentration polarization technique and they were simply isolated from the rest of the sample by unfolding the device.

Original language	English
Pages (from-to)	3917-3921
Number of pages	5
Journal	Lab on a Chip
Volume	19
Issue number	23
DOIs	https://doi.org/10.1039/c9lc00796b
Publication status	Published - 2019 Jan 1

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ASJC Scopus subject areas

Bioengineering
Biochemistry
Chemistry(all)
Biomedical Engineering

Cite this

Kim, H., Lee, K. H., Han, S. I., Lee, D., Chung, S., Lee, D., & Lee, J. H. (2019). Origami-paper-based device for microvesicle/exosome preconcentration and isolation. Lab on a Chip, 19(23), 3917-3921. https://doi.org/10.1039/c9lc00796b

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Access to Document

10.1039/c9lc00796b