Abstract
Microvesicles and exosomes are promising liquid biopsy biomarkers. However, conventional isolation techniques damage and contaminate the biomarkers. We developed an origami-paper-based device for effective isolation of biomarkers with less damage and in fewer steps. The multi-folded device enables the preconcentration of the microvesicles/exosomes on specific layers (∼5-fold) by the ion concentration polarization technique and they were simply isolated from the rest of the sample by unfolding the device.
| Original language | English |
|---|---|
| Pages (from-to) | 3917-3921 |
| Number of pages | 5 |
| Journal | Lab on a Chip |
| Volume | 19 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - 2019 Dec 7 |
ASJC Scopus subject areas
- Bioengineering
- Biochemistry
- Chemistry(all)
- Biomedical Engineering
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Kim, H., Lee, K. H., Han, S. I., Lee, D., Chung, S., Lee, D., & Lee, J. H. (2019). Origami-paper-based device for microvesicle/exosome preconcentration and isolation. Lab on a Chip, 19(23), 3917-3921. https://doi.org/10.1039/c9lc00796b