Origami-paper-based device for microvesicle/exosome preconcentration and isolation

Hyerin Kim, Kyu Hyoung Lee, Sung Il Han, Dongho Lee, Seok Chung, Dohwan Lee, Jeong Hoon Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)


Microvesicles and exosomes are promising liquid biopsy biomarkers. However, conventional isolation techniques damage and contaminate the biomarkers. We developed an origami-paper-based device for effective isolation of biomarkers with less damage and in fewer steps. The multi-folded device enables the preconcentration of the microvesicles/exosomes on specific layers (∼5-fold) by the ion concentration polarization technique and they were simply isolated from the rest of the sample by unfolding the device.

Original languageEnglish
Pages (from-to)3917-3921
Number of pages5
JournalLab on a Chip
Issue number23
Publication statusPublished - 2019 Jan 1


ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

Cite this

Kim, H., Lee, K. H., Han, S. I., Lee, D., Chung, S., Lee, D., & Lee, J. H. (2019). Origami-paper-based device for microvesicle/exosome preconcentration and isolation. Lab on a Chip, 19(23), 3917-3921. https://doi.org/10.1039/c9lc00796b