Orthogonality and compatibility between Tsc and Fmoc amino-protecting groups

Jin Seok Choi, Hunhui Kang, Nakcheol Jeong, Hogyu Han

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

New deprotection conditions that provide a complete orthogonality between Tsc and Fmoc amino-protecting groups are described. The potential of these orthogonal deprotection conditions was then demonstrated by the efficient solid-phase synthesis of branched peptides 20 and 21 using doubly protected amino acids such as Tsc-Lys(Fmoc)-OH 4c and Fmoc-Lys(Tsc)-OH 4d.

Original languageEnglish
Pages (from-to)2493-2503
Number of pages11
JournalTetrahedron
Volume61
Issue number9
DOIs
Publication statusPublished - 2005 Feb 28

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Solid-Phase Synthesis Techniques
Amino Acids
Peptides

Keywords

  • Amino-protecting group
  • Branched peptide
  • Fmoc
  • Orthogonal deprotection
  • Tsc

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Orthogonality and compatibility between Tsc and Fmoc amino-protecting groups. / Choi, Jin Seok; Kang, Hunhui; Jeong, Nakcheol; Han, Hogyu.

In: Tetrahedron, Vol. 61, No. 9, 28.02.2005, p. 2493-2503.

Research output: Contribution to journalArticle

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