Oseltamivir-resistant influenza viruses isolated in South Korea from 2005 to 2010

Han Gil Cho, Jang Hoon Choi, Hyun Kyung Lee, Su Kyoung Mun, Jong Bok Lee, Eek Hoon Jho, Chun Kang, Young Hee Lim

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Abstract

South Korean isolates of oseltamivir-resistant influenza viruses from 2005-2010 were investigated with a total 491 influenza viruses identified from 1702 specimens. Neuraminidase genes from 342 influenza viruses (71 A/H1N1, 74 pandemic A/H1N1 2009, 117 A/H3N2, and 80 B) were analyzed by RT-PCR with molecular markers for oseltamivir resistance. The H274Y mutation in the NA protein was identified in 100 % (n=40) of A/H1N1 viruses circulating in 2008-2009. Influenza A/H1N1 viruses harboring the H274Y substitution exhibited, on average, a 626-fold reduction in oseltamivir susceptibility and clustered with the A/Norway/1736/2007 strain. Close and timely monitoring for resistance to clinically available influenza antivirals should be consistently performed.

Original languageEnglish
Pages (from-to)2365-2370
Number of pages6
JournalArchives of virology
Volume158
Issue number11
DOIs
Publication statusPublished - 2013 Nov

Keywords

  • Influenza viruses
  • Neuraminidase
  • Oseltamivir resistance

ASJC Scopus subject areas

  • Virology

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    Cho, H. G., Choi, J. H., Lee, H. K., Mun, S. K., Lee, J. B., Jho, E. H., Kang, C., & Lim, Y. H. (2013). Oseltamivir-resistant influenza viruses isolated in South Korea from 2005 to 2010. Archives of virology, 158(11), 2365-2370. https://doi.org/10.1007/s00705-013-1734-3