Abstract
Genome scans for osteoarthritis (OA) have yielded inconsistent results. The absence of replication of linkage might be due to the lack of power of individual studies. A meta-analysis of published data was performed to assess evidence for linkage of OA across genome scan studies. Three OA whole-genome scans including 893 families with 3,000 affected individuals were used for genome scan meta-analysis (GSMA). A total of five bins lie above 95% confidence level (P=0.05) and one bin is above 99% confidence level (P=0.01) in OA GSMA; bins 7.6 (7q34-7q36.3, P sumrnk =0.0035), 11.3 (11p12-11q13.4), 6.3 (6p21.1-6q15), 2.8 (2q31.1-2q34) and 15.3 (15q21.3-15q26.1). The highest summed bin was bins 7.6. In conclusion, the OA GSMA has shown that chromosome 7q34-7q36.3 have the highest summed rank and four additional loci with significant summed ranks across studies.
| Original language | English |
|---|---|
| Pages (from-to) | 996-1000 |
| Number of pages | 5 |
| Journal | Rheumatology International |
| Volume | 26 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2006 Sep 1 |
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Keywords
- Genome scan
- Linkage
- Meta-analysis
- Osteoarthritis
ASJC Scopus subject areas
- Immunology and Allergy
- Rheumatology
- Immunology
Cite this
Osteoarthritis susceptibility loci defined by genome scan meta-analysis. / Lee, Young Ho; Rho, Young Hee; Choi, Sungjae; Ji, Jong Dae; Song, Gwan Gyu.
In: Rheumatology International, Vol. 26, No. 11, 01.09.2006, p. 996-1000.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Osteoarthritis susceptibility loci defined by genome scan meta-analysis
AU - Lee, Young Ho
AU - Rho, Young Hee
AU - Choi, Sungjae
AU - Ji, Jong Dae
AU - Song, Gwan Gyu
PY - 2006/9/1
Y1 - 2006/9/1
N2 - Genome scans for osteoarthritis (OA) have yielded inconsistent results. The absence of replication of linkage might be due to the lack of power of individual studies. A meta-analysis of published data was performed to assess evidence for linkage of OA across genome scan studies. Three OA whole-genome scans including 893 families with 3,000 affected individuals were used for genome scan meta-analysis (GSMA). A total of five bins lie above 95% confidence level (P=0.05) and one bin is above 99% confidence level (P=0.01) in OA GSMA; bins 7.6 (7q34-7q36.3, P sumrnk =0.0035), 11.3 (11p12-11q13.4), 6.3 (6p21.1-6q15), 2.8 (2q31.1-2q34) and 15.3 (15q21.3-15q26.1). The highest summed bin was bins 7.6. In conclusion, the OA GSMA has shown that chromosome 7q34-7q36.3 have the highest summed rank and four additional loci with significant summed ranks across studies.
AB - Genome scans for osteoarthritis (OA) have yielded inconsistent results. The absence of replication of linkage might be due to the lack of power of individual studies. A meta-analysis of published data was performed to assess evidence for linkage of OA across genome scan studies. Three OA whole-genome scans including 893 families with 3,000 affected individuals were used for genome scan meta-analysis (GSMA). A total of five bins lie above 95% confidence level (P=0.05) and one bin is above 99% confidence level (P=0.01) in OA GSMA; bins 7.6 (7q34-7q36.3, P sumrnk =0.0035), 11.3 (11p12-11q13.4), 6.3 (6p21.1-6q15), 2.8 (2q31.1-2q34) and 15.3 (15q21.3-15q26.1). The highest summed bin was bins 7.6. In conclusion, the OA GSMA has shown that chromosome 7q34-7q36.3 have the highest summed rank and four additional loci with significant summed ranks across studies.
KW - Genome scan
KW - Linkage
KW - Meta-analysis
KW - Osteoarthritis
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U2 - 10.1007/s00296-006-0120-9
DO - 10.1007/s00296-006-0120-9
M3 - Article
VL - 26
SP - 996
EP - 1000
JO - Rheumatology International
JF - Rheumatology International
SN - 0172-8172
IS - 11
ER -