Abstract
Genome scans for osteoarthritis (OA) have yielded inconsistent results. The absence of replication of linkage might be due to the lack of power of individual studies. A meta-analysis of published data was performed to assess evidence for linkage of OA across genome scan studies. Three OA whole-genome scans including 893 families with 3,000 affected individuals were used for genome scan meta-analysis (GSMA). A total of five bins lie above 95% confidence level (P=0.05) and one bin is above 99% confidence level (P=0.01) in OA GSMA; bins 7.6 (7q34-7q36.3, P sumrnk =0.0035), 11.3 (11p12-11q13.4), 6.3 (6p21.1-6q15), 2.8 (2q31.1-2q34) and 15.3 (15q21.3-15q26.1). The highest summed bin was bins 7.6. In conclusion, the OA GSMA has shown that chromosome 7q34-7q36.3 have the highest summed rank and four additional loci with significant summed ranks across studies.
| Original language | English |
|---|---|
| Pages (from-to) | 996-1000 |
| Number of pages | 5 |
| Journal | Rheumatology International |
| Volume | 26 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2006 Sep |
Keywords
- Genome scan
- Linkage
- Meta-analysis
- Osteoarthritis
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology