Osteoblasts are the centerpiece of the metastatic bone microenvironment

Hyo Min Jeong, Sun Wook Cho, Serkin Park

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

The tumor microenvironment is comprised of diverse stromal cell populations in addition to tumor cells. Increasing evidence now clearly supports the role of microenvironment stromal cells in tumor progression and metastasis, yet the regulatory mechanisms and interactions among tumor and stromal cells remain to be elucidated. Bone metastasis is the major problem in many types of human malignancies including prostate, breast and lung cancers, and the biological basis of bone metastasis let alone curative approaches are largely undetermined. Among the many types of stromal cells in bone, osteoblasts are shown to be an important player. In this regard, osteoblasts are a key target cell type in the development of bone metastasis, but there are currently no drugs or therapeutic approaches are available that specifically target osteoblasts. This review paper summarizes the current knowledge on osteoblasts in the metastatic tumor microenvironment, aiming to provide clues and directions for future research endeavor.

Original languageEnglish
Pages (from-to)485-492
Number of pages8
JournalEndocrinology and Metabolism
Volume31
Issue number4
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • Bone and bones
  • Microenvironment
  • Neoplasm metastasis
  • Neoplasms
  • Osteoblasts
  • Osteoclasts

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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