Osteoblasts are the centerpiece of the metastatic bone microenvironment

Hyo Min Jeong, Sun Wook Cho, Serkin Park

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

The tumor microenvironment is comprised of diverse stromal cell populations in addition to tumor cells. Increasing evidence now clearly supports the role of microenvironment stromal cells in tumor progression and metastasis, yet the regulatory mechanisms and interactions among tumor and stromal cells remain to be elucidated. Bone metastasis is the major problem in many types of human malignancies including prostate, breast and lung cancers, and the biological basis of bone metastasis let alone curative approaches are largely undetermined. Among the many types of stromal cells in bone, osteoblasts are shown to be an important player. In this regard, osteoblasts are a key target cell type in the development of bone metastasis, but there are currently no drugs or therapeutic approaches are available that specifically target osteoblasts. This review paper summarizes the current knowledge on osteoblasts in the metastatic tumor microenvironment, aiming to provide clues and directions for future research endeavor.

Original languageEnglish
Pages (from-to)485-492
Number of pages8
JournalEndocrinology and Metabolism
Volume31
Issue number4
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Stromal Cells
Osteoblasts
Neoplasm Metastasis
Bone and Bones
Tumor Microenvironment
Neoplasms
Bone Development
Lung Neoplasms
Prostatic Neoplasms
Breast Neoplasms
Pharmaceutical Preparations
Population
Therapeutics

Keywords

  • Bone and bones
  • Microenvironment
  • Neoplasm metastasis
  • Neoplasms
  • Osteoblasts
  • Osteoclasts

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Osteoblasts are the centerpiece of the metastatic bone microenvironment. / Jeong, Hyo Min; Cho, Sun Wook; Park, Serkin.

In: Endocrinology and Metabolism, Vol. 31, No. 4, 01.01.2016, p. 485-492.

Research output: Contribution to journalReview article

Jeong, Hyo Min ; Cho, Sun Wook ; Park, Serkin. / Osteoblasts are the centerpiece of the metastatic bone microenvironment. In: Endocrinology and Metabolism. 2016 ; Vol. 31, No. 4. pp. 485-492.
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