Osteogenesis and new bone formation of alendronate-immobilized porous PLGA microspheres in a rat calvarial defect model

Jae Yong Lee, Sung Eun Kim, Young Pil Yun, Sung Wook Choi, Daniel I. Jeon, Hak Jun Kim, Kyeongsoon Park, Hae Ryong Song

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In this study, we evaluated in vitro osteogenic differentiation and in vivo new bone formation using the alendronate-releasing porous PLGA microsphere (Aln/PMS) system in rats with a critical-sized calvarial defect. Aln/PMS system significantly enhanced in vitro osteogenic differentiation and maturation, showing significantly enhanced ALP activity, calcium deposition and the expression of osteocalcin and osteopontin, relative to PMS alone. Also, micro-CT analyses and histology results suggested that Aln/PMS system increased mineralization and bone matrix formation compared to PMS alone. This study demonstrated that the local delivery of Aln, a potent-osteoinductive factor, significantly enhances rabbit adipose-derived stem cells osteogenesis and bone regeneration.

Original languageEnglish
Pages (from-to)277-286
Number of pages10
JournalJournal of Industrial and Engineering Chemistry
Volume52
DOIs
Publication statusPublished - 2017 Aug 25

Fingerprint

Alendronate
Microspheres
Rats
Bone
Defects
Osteopontin
Histology
Osteocalcin
Stem cells
Calcium
polylactic acid-polyglycolic acid copolymer

Keywords

  • Alendronate (Aln)
  • Bone regeneration
  • Calvarial defect model
  • Porous PLGA microspheres (PMSs)
  • Rabbit adipose-derived stem cells (rADSCs)

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Osteogenesis and new bone formation of alendronate-immobilized porous PLGA microspheres in a rat calvarial defect model. / Lee, Jae Yong; Kim, Sung Eun; Yun, Young Pil; Choi, Sung Wook; Jeon, Daniel I.; Kim, Hak Jun; Park, Kyeongsoon; Song, Hae Ryong.

In: Journal of Industrial and Engineering Chemistry, Vol. 52, 25.08.2017, p. 277-286.

Research output: Contribution to journalArticle

Lee, Jae Yong ; Kim, Sung Eun ; Yun, Young Pil ; Choi, Sung Wook ; Jeon, Daniel I. ; Kim, Hak Jun ; Park, Kyeongsoon ; Song, Hae Ryong. / Osteogenesis and new bone formation of alendronate-immobilized porous PLGA microspheres in a rat calvarial defect model. In: Journal of Industrial and Engineering Chemistry. 2017 ; Vol. 52. pp. 277-286.
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