Osteogenesis and new bone formation of alendronate-immobilized porous PLGA microspheres in a rat calvarial defect model

Jae Yong Lee, Sung Eun Kim, Young Pil Yun, Sung Wook Choi, Daniel I. Jeon, Hak Jun Kim, Kyeongsoon Park, Hae Ryong Song

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In this study, we evaluated in vitro osteogenic differentiation and in vivo new bone formation using the alendronate-releasing porous PLGA microsphere (Aln/PMS) system in rats with a critical-sized calvarial defect. Aln/PMS system significantly enhanced in vitro osteogenic differentiation and maturation, showing significantly enhanced ALP activity, calcium deposition and the expression of osteocalcin and osteopontin, relative to PMS alone. Also, micro-CT analyses and histology results suggested that Aln/PMS system increased mineralization and bone matrix formation compared to PMS alone. This study demonstrated that the local delivery of Aln, a potent-osteoinductive factor, significantly enhances rabbit adipose-derived stem cells osteogenesis and bone regeneration.

Original languageEnglish
Pages (from-to)277-286
Number of pages10
JournalJournal of Industrial and Engineering Chemistry
Volume52
DOIs
Publication statusPublished - 2017 Aug 25

Keywords

  • Alendronate (Aln)
  • Bone regeneration
  • Calvarial defect model
  • Porous PLGA microspheres (PMSs)
  • Rabbit adipose-derived stem cells (rADSCs)

ASJC Scopus subject areas

  • Chemical Engineering(all)

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