Osteopontin expression correlates with invasiveness in cervical cancer

Jae Yun Song, Jae Kwan Lee, Nak Woo Lee, Bom Woo Yeom, Sun Haeng Kim, Kyu Wan Lee

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)


    Aim: Osteopontin is a secreted, integrin-binding glycophosphoprotein that is overexpressed in many types of cancers and appears to be involved in carcinogenesis and cancer progression. To understand the role of osteopontin in carcinogenesis of cervical cancer, this study was designed to determine whether osteopontin is expressed in cervical cancer and carcinoma in situ (CIS) tissue as well as in normal cervical tissue. Methods: The expression of osteopontin was immunohistochemically analysed from 68 normal cervix, 55 CIS and 52 invasive cervical cancer tissues using a paraffin-embedded tissue array. Immunostaining was evaluated by intensity and the percentage of stained cells. Results: Osteopontin expression in normal, CIS and cervical cancer tissues was two of 68 (2.9%), 43 of 55 (78.2%) and 46 of 52 (88.4%), respectively (P < 0.01). High intensity (strong positive)/high proportion (more than 50%) staining seen in CIS and cervical cancer tissue samples was 45 of 55 (81.8%)/22 of 55 (40.0%) and 50 of 52 (96.2%)/31 of 52 (59.7%), respectively (P = 0.029 and P = 0.054). There was no significant correlation between the immunostaining score and stage and the immunostaining score and survival. Conclusion: Osteopontin may have a potential use as a diagnostic factor for cervical cancer and osteopontin expression is closely correlated with carcinogenesis and invasion of cervical cancer.

    Original languageEnglish
    Pages (from-to)434-438
    Number of pages5
    JournalAustralian and New Zealand Journal of Obstetrics and Gynaecology
    Issue number4
    Publication statusPublished - 2009 Aug


    • Immunohistochemistry
    • Neoplastic cell transformation
    • Osteopontin
    • Tissue array analysis
    • Uterine cervical neoplasms

    ASJC Scopus subject areas

    • Obstetrics and Gynaecology


    Dive into the research topics of 'Osteopontin expression correlates with invasiveness in cervical cancer'. Together they form a unique fingerprint.

    Cite this