Osteosarcoma in pre-adolescent patients

W. H. Cho, S. Y. Lee, W. S. Song, Jong Hoon Park

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The medical records of 38 pre-adolescent (aged ≤ 10 years) and 43 adolescent (aged 11 - 15 years) patients with primary osteosarcoma treated using the same protocol were reviewed in order to determine whether the clinical features and prognosis differed between these two groups. Gender, tumour location, tumour size, serum levels of alkaline phosphatase and lactic dehydrogenase before treatment, and chemotherapy-induced tumour necrosis were recorded, together with survival data. These parameters were compared in the two groups, and their prognostic significance was evaluated in the pre-adolescent patients. There were no statistically significant differences in the clinical parameters between pre-adolescent and adolescent patients. Only a poor level of chemotherapy-induced tumour necrosis was significantly associated with a poor prognosis in pre-adolescent patients. This study indicates that osteosarcoma behaviour is similar in pre-adolescent and adolescent patients, and there appears to be little justification for adopting diffetent therapies in these two groups.

Original languageEnglish
Pages (from-to)676-681
Number of pages6
JournalJournal of International Medical Research
Volume34
Issue number6
DOIs
Publication statusPublished - 2006 Jan 1
Externally publishedYes

Fingerprint

Osteosarcoma
Tumors
Chemotherapy
Alkaline Phosphatase
Neoplasms
Oxidoreductases
Necrosis
Drug Therapy
Medical Records
Milk
Survival
Therapeutics
Serum

Keywords

  • Adolescence
  • Chemotherapy
  • Osteosarcoma
  • Paeditrics
  • Pre-adolescence
  • Prognostic factors
  • Surgery

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

Cite this

Osteosarcoma in pre-adolescent patients. / Cho, W. H.; Lee, S. Y.; Song, W. S.; Park, Jong Hoon.

In: Journal of International Medical Research, Vol. 34, No. 6, 01.01.2006, p. 676-681.

Research output: Contribution to journalArticle

Cho, W. H. ; Lee, S. Y. ; Song, W. S. ; Park, Jong Hoon. / Osteosarcoma in pre-adolescent patients. In: Journal of International Medical Research. 2006 ; Vol. 34, No. 6. pp. 676-681.
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