Outcomes of follow-up CT for small (5-10-mm) arterially enhancing nodules in the liver and risk factors for developing hepatocellular carcinoma in a surveillance population

Min Jung Park, Young Sun Kim, Won Jae Lee, Hyo K. Lim, Hyunchul Rhim, Jongmee Lee

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective:: To evaluate the outcomes of small (5-10 mm), arterially enhancing nodules (SAENs) shown exclusively at the hepatic arterial phase of CT in a hepatocellular carcinoma (HCC) surveillance population and to determine risk factors for developing HCC. Methods:: The study population included 112 patients (male:female=100:12; aged 36-92 years) with 175 SAENs who were at risk of HCC. We evaluated serial changes during follow-up (1.4-41.8 months, mean 35.7 months) and analysed the initial CT findings of SAENs and the accompanying lesions to elucidate the risk factors for HCC development. Results:: Of 175 SAENs, 101(57.7%) disappeared and 34(19.4%) persisted. Forty SAENs (22.9%) became HCC in 33 patients (29.5%). Presence of HCC treatment history (p=0.005, risk ratio=7.429), a larger size of SAEN (p=0.003, risk ratio=1.630), presence of coexistent HCC (p=0.021, risk ratio=3.777) and absence of coexistent typical arterioportal shunts (p=0.003, risk ratio=4.459) turned out to be independently significant risk factors for future development of HCC. Conclusion:: SAENs were frequently seen in an HCC surveillance population and have a 22.9% probability of becoming HCC on a per-lesion basis. Risk increased particularly when the lesion was associated with a previous or concurrent HCC, a large size or found without a coexistent typical arterioportal shunt.

Original languageEnglish
Pages (from-to)2397-2404
Number of pages8
JournalEuropean Radiology
Volume20
Issue number10
DOIs
Publication statusPublished - 2010 Oct 1

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Population Surveillance
Hepatocellular Carcinoma
Liver
Odds Ratio

Keywords

  • Chronic liver disease
  • Computed tomography
  • Hepatocarcinogenesis
  • Hepatocellular carcinoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Outcomes of follow-up CT for small (5-10-mm) arterially enhancing nodules in the liver and risk factors for developing hepatocellular carcinoma in a surveillance population. / Park, Min Jung; Kim, Young Sun; Lee, Won Jae; Lim, Hyo K.; Rhim, Hyunchul; Lee, Jongmee.

In: European Radiology, Vol. 20, No. 10, 01.10.2010, p. 2397-2404.

Research output: Contribution to journalArticle

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title = "Outcomes of follow-up CT for small (5-10-mm) arterially enhancing nodules in the liver and risk factors for developing hepatocellular carcinoma in a surveillance population",
abstract = "Objective:: To evaluate the outcomes of small (5-10 mm), arterially enhancing nodules (SAENs) shown exclusively at the hepatic arterial phase of CT in a hepatocellular carcinoma (HCC) surveillance population and to determine risk factors for developing HCC. Methods:: The study population included 112 patients (male:female=100:12; aged 36-92 years) with 175 SAENs who were at risk of HCC. We evaluated serial changes during follow-up (1.4-41.8 months, mean 35.7 months) and analysed the initial CT findings of SAENs and the accompanying lesions to elucidate the risk factors for HCC development. Results:: Of 175 SAENs, 101(57.7{\%}) disappeared and 34(19.4{\%}) persisted. Forty SAENs (22.9{\%}) became HCC in 33 patients (29.5{\%}). Presence of HCC treatment history (p=0.005, risk ratio=7.429), a larger size of SAEN (p=0.003, risk ratio=1.630), presence of coexistent HCC (p=0.021, risk ratio=3.777) and absence of coexistent typical arterioportal shunts (p=0.003, risk ratio=4.459) turned out to be independently significant risk factors for future development of HCC. Conclusion:: SAENs were frequently seen in an HCC surveillance population and have a 22.9{\%} probability of becoming HCC on a per-lesion basis. Risk increased particularly when the lesion was associated with a previous or concurrent HCC, a large size or found without a coexistent typical arterioportal shunt.",
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AU - Kim, Young Sun

AU - Lee, Won Jae

AU - Lim, Hyo K.

AU - Rhim, Hyunchul

AU - Lee, Jongmee

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N2 - Objective:: To evaluate the outcomes of small (5-10 mm), arterially enhancing nodules (SAENs) shown exclusively at the hepatic arterial phase of CT in a hepatocellular carcinoma (HCC) surveillance population and to determine risk factors for developing HCC. Methods:: The study population included 112 patients (male:female=100:12; aged 36-92 years) with 175 SAENs who were at risk of HCC. We evaluated serial changes during follow-up (1.4-41.8 months, mean 35.7 months) and analysed the initial CT findings of SAENs and the accompanying lesions to elucidate the risk factors for HCC development. Results:: Of 175 SAENs, 101(57.7%) disappeared and 34(19.4%) persisted. Forty SAENs (22.9%) became HCC in 33 patients (29.5%). Presence of HCC treatment history (p=0.005, risk ratio=7.429), a larger size of SAEN (p=0.003, risk ratio=1.630), presence of coexistent HCC (p=0.021, risk ratio=3.777) and absence of coexistent typical arterioportal shunts (p=0.003, risk ratio=4.459) turned out to be independently significant risk factors for future development of HCC. Conclusion:: SAENs were frequently seen in an HCC surveillance population and have a 22.9% probability of becoming HCC on a per-lesion basis. Risk increased particularly when the lesion was associated with a previous or concurrent HCC, a large size or found without a coexistent typical arterioportal shunt.

AB - Objective:: To evaluate the outcomes of small (5-10 mm), arterially enhancing nodules (SAENs) shown exclusively at the hepatic arterial phase of CT in a hepatocellular carcinoma (HCC) surveillance population and to determine risk factors for developing HCC. Methods:: The study population included 112 patients (male:female=100:12; aged 36-92 years) with 175 SAENs who were at risk of HCC. We evaluated serial changes during follow-up (1.4-41.8 months, mean 35.7 months) and analysed the initial CT findings of SAENs and the accompanying lesions to elucidate the risk factors for HCC development. Results:: Of 175 SAENs, 101(57.7%) disappeared and 34(19.4%) persisted. Forty SAENs (22.9%) became HCC in 33 patients (29.5%). Presence of HCC treatment history (p=0.005, risk ratio=7.429), a larger size of SAEN (p=0.003, risk ratio=1.630), presence of coexistent HCC (p=0.021, risk ratio=3.777) and absence of coexistent typical arterioportal shunts (p=0.003, risk ratio=4.459) turned out to be independently significant risk factors for future development of HCC. Conclusion:: SAENs were frequently seen in an HCC surveillance population and have a 22.9% probability of becoming HCC on a per-lesion basis. Risk increased particularly when the lesion was associated with a previous or concurrent HCC, a large size or found without a coexistent typical arterioportal shunt.

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