Abstract
Objective:: To evaluate the outcomes of small (5-10 mm), arterially enhancing nodules (SAENs) shown exclusively at the hepatic arterial phase of CT in a hepatocellular carcinoma (HCC) surveillance population and to determine risk factors for developing HCC. Methods:: The study population included 112 patients (male:female=100:12; aged 36-92 years) with 175 SAENs who were at risk of HCC. We evaluated serial changes during follow-up (1.4-41.8 months, mean 35.7 months) and analysed the initial CT findings of SAENs and the accompanying lesions to elucidate the risk factors for HCC development. Results:: Of 175 SAENs, 101(57.7%) disappeared and 34(19.4%) persisted. Forty SAENs (22.9%) became HCC in 33 patients (29.5%). Presence of HCC treatment history (p=0.005, risk ratio=7.429), a larger size of SAEN (p=0.003, risk ratio=1.630), presence of coexistent HCC (p=0.021, risk ratio=3.777) and absence of coexistent typical arterioportal shunts (p=0.003, risk ratio=4.459) turned out to be independently significant risk factors for future development of HCC. Conclusion:: SAENs were frequently seen in an HCC surveillance population and have a 22.9% probability of becoming HCC on a per-lesion basis. Risk increased particularly when the lesion was associated with a previous or concurrent HCC, a large size or found without a coexistent typical arterioportal shunt.
| Original language | English |
|---|---|
| Pages (from-to) | 2397-2404 |
| Number of pages | 8 |
| Journal | European Radiology |
| Volume | 20 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2010 Oct 1 |
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Keywords
- Chronic liver disease
- Computed tomography
- Hepatocarcinogenesis
- Hepatocellular carcinoma
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Outcomes of follow-up CT for small (5-10-mm) arterially enhancing nodules in the liver and risk factors for developing hepatocellular carcinoma in a surveillance population. / Park, Min Jung; Kim, Young Sun; Lee, Won Jae; Lim, Hyo K.; Rhim, Hyunchul; Lee, Jongmee.
In: European Radiology, Vol. 20, No. 10, 01.10.2010, p. 2397-2404.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Outcomes of follow-up CT for small (5-10-mm) arterially enhancing nodules in the liver and risk factors for developing hepatocellular carcinoma in a surveillance population
AU - Park, Min Jung
AU - Kim, Young Sun
AU - Lee, Won Jae
AU - Lim, Hyo K.
AU - Rhim, Hyunchul
AU - Lee, Jongmee
PY - 2010/10/1
Y1 - 2010/10/1
N2 - Objective:: To evaluate the outcomes of small (5-10 mm), arterially enhancing nodules (SAENs) shown exclusively at the hepatic arterial phase of CT in a hepatocellular carcinoma (HCC) surveillance population and to determine risk factors for developing HCC. Methods:: The study population included 112 patients (male:female=100:12; aged 36-92 years) with 175 SAENs who were at risk of HCC. We evaluated serial changes during follow-up (1.4-41.8 months, mean 35.7 months) and analysed the initial CT findings of SAENs and the accompanying lesions to elucidate the risk factors for HCC development. Results:: Of 175 SAENs, 101(57.7%) disappeared and 34(19.4%) persisted. Forty SAENs (22.9%) became HCC in 33 patients (29.5%). Presence of HCC treatment history (p=0.005, risk ratio=7.429), a larger size of SAEN (p=0.003, risk ratio=1.630), presence of coexistent HCC (p=0.021, risk ratio=3.777) and absence of coexistent typical arterioportal shunts (p=0.003, risk ratio=4.459) turned out to be independently significant risk factors for future development of HCC. Conclusion:: SAENs were frequently seen in an HCC surveillance population and have a 22.9% probability of becoming HCC on a per-lesion basis. Risk increased particularly when the lesion was associated with a previous or concurrent HCC, a large size or found without a coexistent typical arterioportal shunt.
AB - Objective:: To evaluate the outcomes of small (5-10 mm), arterially enhancing nodules (SAENs) shown exclusively at the hepatic arterial phase of CT in a hepatocellular carcinoma (HCC) surveillance population and to determine risk factors for developing HCC. Methods:: The study population included 112 patients (male:female=100:12; aged 36-92 years) with 175 SAENs who were at risk of HCC. We evaluated serial changes during follow-up (1.4-41.8 months, mean 35.7 months) and analysed the initial CT findings of SAENs and the accompanying lesions to elucidate the risk factors for HCC development. Results:: Of 175 SAENs, 101(57.7%) disappeared and 34(19.4%) persisted. Forty SAENs (22.9%) became HCC in 33 patients (29.5%). Presence of HCC treatment history (p=0.005, risk ratio=7.429), a larger size of SAEN (p=0.003, risk ratio=1.630), presence of coexistent HCC (p=0.021, risk ratio=3.777) and absence of coexistent typical arterioportal shunts (p=0.003, risk ratio=4.459) turned out to be independently significant risk factors for future development of HCC. Conclusion:: SAENs were frequently seen in an HCC surveillance population and have a 22.9% probability of becoming HCC on a per-lesion basis. Risk increased particularly when the lesion was associated with a previous or concurrent HCC, a large size or found without a coexistent typical arterioportal shunt.
KW - Chronic liver disease
KW - Computed tomography
KW - Hepatocarcinogenesis
KW - Hepatocellular carcinoma
UR - http://www.scopus.com/inward/record.url?scp=77957884475&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957884475&partnerID=8YFLogxK
U2 - 10.1007/s00330-010-1810-y
DO - 10.1007/s00330-010-1810-y
M3 - Article
C2 - 20559837
AN - SCOPUS:77957884475
VL - 20
SP - 2397
EP - 2404
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 10
ER -