Outcomes of Gamma Knife surgery for trigeminal neuralgia secondary to vertebrobasilar ectasia

Clinical article

Kyung-Jae Park, Douglas Kondziolka, Hideyuki Kano, Oren Berkowitz, Safee Faraz Ahmed, Xiaomin Liu, Ajay Niranjan, John C. Flick Inger, L. Dade Lunsford

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Object. Vertebrobasilar ectasia (VBE) is an unusual cause of trigeminal neuralgia (TN). The surgical options for patients with medically refractory pain include percutaneous or microsurgical rhizotomy and microvascular decompression (MVD). All such procedures can be technically challenging. This report evaluates the response to a minimally invasive procedure, Gamma Knife surgery (GKS), in patients with TN associated with severe vascular compression caused by VBE. Methods. Twenty patients underwent GKS for medically refractory TN associated with VBE. The median patient age was 74 years (range 48-95 years). Prior surgical procedures had failed in 11 patients (55%). In 9 patients (45%), GKS was the first procedure they had undergone. The median target dose for GKS was 80 Gy (range 75-85 Gy). The median follow-up was 29 months (range 8-123 months) after GKS. The treatment outcomes were compared with 80 case-matched controls who underwent GKS for TN not associated with VBE. Results. Intraoperative MR imaging or CT scanning revealed VBE that deformed the brainstem in 50% of patients. The trigeminal nerve was displaced in cephalad or lateral planes in 60%. In 4 patients (20%), the authors could identify only the distal cisternal component of the trigeminal nerve as it entered into the Meckel cave. After GKS, 15 patients (75%) achieved initial pain relief that was adequate or better, with or without medication (Barrow Neurological Institute [BNI] pain scale, Grades I-IIIb). The median time until pain relief was 5 weeks (range 1 day-6 months). Twelve patients (60%) with initial pain relief reported recurrent pain between 3 and 43 months after GKS (median 12 months). Pain relief was maintained in 53% at 1 year, 38% at 2 years, and 10% at 5 years. Some degree of facial sensory dysfunction occurred in 10% of patients. Eventually, 14 (70%) of the 20 patients underwent an additional surgical procedure including repeat GKS, percutaneous procedure, or MVD at a median of 14 months (range 5-50 months) after the initial GKS. At the last follow-up, 15 patients (75%) had satisfactory pain control (BNI Grades I-IIIb), but 5 patients (25%) continued to have unsatisfactory pain control (BNI Grade IV or V). Compared with patients without VBE, patients with VBE were much less likely to have initial (p = 0.025) or lasting (p = 0.006) pain relief. Conclusions. Pain control rates of GKS in patients with TN associated with VBE were inferior to those of patients without VBE. Multimodality surgical or medical management strategies were required in most patients with VBE.

Original languageEnglish
Pages (from-to)73-81
Number of pages9
JournalJournal of Neurosurgery
Volume116
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

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Pathologic Dilatations
Trigeminal Neuralgia
Pain
Microvascular Decompression Surgery
Trigeminal Nerve
Rhizotomy
Intractable Pain

Keywords

  • Gamma Knife surgery
  • Radiosurgery
  • Stereotactic radiosurgery
  • Trigeminal neuralgia
  • Vertebrobasilar ectasia

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Outcomes of Gamma Knife surgery for trigeminal neuralgia secondary to vertebrobasilar ectasia : Clinical article. / Park, Kyung-Jae; Kondziolka, Douglas; Kano, Hideyuki; Berkowitz, Oren; Ahmed, Safee Faraz; Liu, Xiaomin; Niranjan, Ajay; Flick Inger, John C.; Dade Lunsford, L.

In: Journal of Neurosurgery, Vol. 116, No. 1, 01.01.2012, p. 73-81.

Research output: Contribution to journalArticle

Park, K-J, Kondziolka, D, Kano, H, Berkowitz, O, Ahmed, SF, Liu, X, Niranjan, A, Flick Inger, JC & Dade Lunsford, L 2012, 'Outcomes of Gamma Knife surgery for trigeminal neuralgia secondary to vertebrobasilar ectasia: Clinical article', Journal of Neurosurgery, vol. 116, no. 1, pp. 73-81. https://doi.org/10.3171/2011.8.JNS11920
Park, Kyung-Jae ; Kondziolka, Douglas ; Kano, Hideyuki ; Berkowitz, Oren ; Ahmed, Safee Faraz ; Liu, Xiaomin ; Niranjan, Ajay ; Flick Inger, John C. ; Dade Lunsford, L. / Outcomes of Gamma Knife surgery for trigeminal neuralgia secondary to vertebrobasilar ectasia : Clinical article. In: Journal of Neurosurgery. 2012 ; Vol. 116, No. 1. pp. 73-81.
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abstract = "Object. Vertebrobasilar ectasia (VBE) is an unusual cause of trigeminal neuralgia (TN). The surgical options for patients with medically refractory pain include percutaneous or microsurgical rhizotomy and microvascular decompression (MVD). All such procedures can be technically challenging. This report evaluates the response to a minimally invasive procedure, Gamma Knife surgery (GKS), in patients with TN associated with severe vascular compression caused by VBE. Methods. Twenty patients underwent GKS for medically refractory TN associated with VBE. The median patient age was 74 years (range 48-95 years). Prior surgical procedures had failed in 11 patients (55{\%}). In 9 patients (45{\%}), GKS was the first procedure they had undergone. The median target dose for GKS was 80 Gy (range 75-85 Gy). The median follow-up was 29 months (range 8-123 months) after GKS. The treatment outcomes were compared with 80 case-matched controls who underwent GKS for TN not associated with VBE. Results. Intraoperative MR imaging or CT scanning revealed VBE that deformed the brainstem in 50{\%} of patients. The trigeminal nerve was displaced in cephalad or lateral planes in 60{\%}. In 4 patients (20{\%}), the authors could identify only the distal cisternal component of the trigeminal nerve as it entered into the Meckel cave. After GKS, 15 patients (75{\%}) achieved initial pain relief that was adequate or better, with or without medication (Barrow Neurological Institute [BNI] pain scale, Grades I-IIIb). The median time until pain relief was 5 weeks (range 1 day-6 months). Twelve patients (60{\%}) with initial pain relief reported recurrent pain between 3 and 43 months after GKS (median 12 months). Pain relief was maintained in 53{\%} at 1 year, 38{\%} at 2 years, and 10{\%} at 5 years. Some degree of facial sensory dysfunction occurred in 10{\%} of patients. Eventually, 14 (70{\%}) of the 20 patients underwent an additional surgical procedure including repeat GKS, percutaneous procedure, or MVD at a median of 14 months (range 5-50 months) after the initial GKS. At the last follow-up, 15 patients (75{\%}) had satisfactory pain control (BNI Grades I-IIIb), but 5 patients (25{\%}) continued to have unsatisfactory pain control (BNI Grade IV or V). Compared with patients without VBE, patients with VBE were much less likely to have initial (p = 0.025) or lasting (p = 0.006) pain relief. Conclusions. Pain control rates of GKS in patients with TN associated with VBE were inferior to those of patients without VBE. Multimodality surgical or medical management strategies were required in most patients with VBE.",
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author = "Kyung-Jae Park and Douglas Kondziolka and Hideyuki Kano and Oren Berkowitz and Ahmed, {Safee Faraz} and Xiaomin Liu and Ajay Niranjan and {Flick Inger}, {John C.} and {Dade Lunsford}, L.",
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AU - Kondziolka, Douglas

AU - Kano, Hideyuki

AU - Berkowitz, Oren

AU - Ahmed, Safee Faraz

AU - Liu, Xiaomin

AU - Niranjan, Ajay

AU - Flick Inger, John C.

AU - Dade Lunsford, L.

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N2 - Object. Vertebrobasilar ectasia (VBE) is an unusual cause of trigeminal neuralgia (TN). The surgical options for patients with medically refractory pain include percutaneous or microsurgical rhizotomy and microvascular decompression (MVD). All such procedures can be technically challenging. This report evaluates the response to a minimally invasive procedure, Gamma Knife surgery (GKS), in patients with TN associated with severe vascular compression caused by VBE. Methods. Twenty patients underwent GKS for medically refractory TN associated with VBE. The median patient age was 74 years (range 48-95 years). Prior surgical procedures had failed in 11 patients (55%). In 9 patients (45%), GKS was the first procedure they had undergone. The median target dose for GKS was 80 Gy (range 75-85 Gy). The median follow-up was 29 months (range 8-123 months) after GKS. The treatment outcomes were compared with 80 case-matched controls who underwent GKS for TN not associated with VBE. Results. Intraoperative MR imaging or CT scanning revealed VBE that deformed the brainstem in 50% of patients. The trigeminal nerve was displaced in cephalad or lateral planes in 60%. In 4 patients (20%), the authors could identify only the distal cisternal component of the trigeminal nerve as it entered into the Meckel cave. After GKS, 15 patients (75%) achieved initial pain relief that was adequate or better, with or without medication (Barrow Neurological Institute [BNI] pain scale, Grades I-IIIb). The median time until pain relief was 5 weeks (range 1 day-6 months). Twelve patients (60%) with initial pain relief reported recurrent pain between 3 and 43 months after GKS (median 12 months). Pain relief was maintained in 53% at 1 year, 38% at 2 years, and 10% at 5 years. Some degree of facial sensory dysfunction occurred in 10% of patients. Eventually, 14 (70%) of the 20 patients underwent an additional surgical procedure including repeat GKS, percutaneous procedure, or MVD at a median of 14 months (range 5-50 months) after the initial GKS. At the last follow-up, 15 patients (75%) had satisfactory pain control (BNI Grades I-IIIb), but 5 patients (25%) continued to have unsatisfactory pain control (BNI Grade IV or V). Compared with patients without VBE, patients with VBE were much less likely to have initial (p = 0.025) or lasting (p = 0.006) pain relief. Conclusions. Pain control rates of GKS in patients with TN associated with VBE were inferior to those of patients without VBE. Multimodality surgical or medical management strategies were required in most patients with VBE.

AB - Object. Vertebrobasilar ectasia (VBE) is an unusual cause of trigeminal neuralgia (TN). The surgical options for patients with medically refractory pain include percutaneous or microsurgical rhizotomy and microvascular decompression (MVD). All such procedures can be technically challenging. This report evaluates the response to a minimally invasive procedure, Gamma Knife surgery (GKS), in patients with TN associated with severe vascular compression caused by VBE. Methods. Twenty patients underwent GKS for medically refractory TN associated with VBE. The median patient age was 74 years (range 48-95 years). Prior surgical procedures had failed in 11 patients (55%). In 9 patients (45%), GKS was the first procedure they had undergone. The median target dose for GKS was 80 Gy (range 75-85 Gy). The median follow-up was 29 months (range 8-123 months) after GKS. The treatment outcomes were compared with 80 case-matched controls who underwent GKS for TN not associated with VBE. Results. Intraoperative MR imaging or CT scanning revealed VBE that deformed the brainstem in 50% of patients. The trigeminal nerve was displaced in cephalad or lateral planes in 60%. In 4 patients (20%), the authors could identify only the distal cisternal component of the trigeminal nerve as it entered into the Meckel cave. After GKS, 15 patients (75%) achieved initial pain relief that was adequate or better, with or without medication (Barrow Neurological Institute [BNI] pain scale, Grades I-IIIb). The median time until pain relief was 5 weeks (range 1 day-6 months). Twelve patients (60%) with initial pain relief reported recurrent pain between 3 and 43 months after GKS (median 12 months). Pain relief was maintained in 53% at 1 year, 38% at 2 years, and 10% at 5 years. Some degree of facial sensory dysfunction occurred in 10% of patients. Eventually, 14 (70%) of the 20 patients underwent an additional surgical procedure including repeat GKS, percutaneous procedure, or MVD at a median of 14 months (range 5-50 months) after the initial GKS. At the last follow-up, 15 patients (75%) had satisfactory pain control (BNI Grades I-IIIb), but 5 patients (25%) continued to have unsatisfactory pain control (BNI Grade IV or V). Compared with patients without VBE, patients with VBE were much less likely to have initial (p = 0.025) or lasting (p = 0.006) pain relief. Conclusions. Pain control rates of GKS in patients with TN associated with VBE were inferior to those of patients without VBE. Multimodality surgical or medical management strategies were required in most patients with VBE.

KW - Gamma Knife surgery

KW - Radiosurgery

KW - Stereotactic radiosurgery

KW - Trigeminal neuralgia

KW - Vertebrobasilar ectasia

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