Ovarian hyper-response to administration of an GnRH-Agonist without gonadotropins

Hyun Tae Park, Hyo Sook Bae, Tak Kim, Sun Haeng Kim

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1 Citation (Scopus)


Several case reports have indicated that a small subgroup of patients may develop ovarian hyperstimulation following the administration of gonadotropin-releasing hormone agonists (GnRHa) without gonadotropins. However, since only few such cases have been published, it is unclear what course to follow in subsequent cycles after ovarian hyperstimulation in the first cycle using only GnRHa. A 33-yr-old woman was referred to in vitro fertilization for oocyte donation. A depot preparation (3.75 mg) of tryptorelin without gonadotropins induced ovarian multifollicular enlargement with high estradiol level, and was followed by human chorionic gonadotropin administration and oocyte retrieval. In a subsequent cycle of the same patient, a low dose of tryptorelin (0.05 mg) did not induce ovarian hyperstimulation, and resulted in clinical pregnancy. This report shows potential management of ovarian hyperstimulation following the administration of GnRHa without gonadotropins.

Original languageEnglish
Pages (from-to)1394-1396
Number of pages3
JournalJournal of Korean medical science
Issue number10
Publication statusPublished - 2011 Oct 1



  • GnRH agonist
  • IVF
  • Ovarian hyperstimulation

ASJC Scopus subject areas

  • Medicine(all)

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