Ovarian hyper-response to administration of an GnRH-Agonist without gonadotropins

Hyun Tae Park, Hyo Sook Bae, Tak Kim, Sun Haeng Kim

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Several case reports have indicated that a small subgroup of patients may develop ovarian hyperstimulation following the administration of gonadotropin-releasing hormone agonists (GnRHa) without gonadotropins. However, since only few such cases have been published, it is unclear what course to follow in subsequent cycles after ovarian hyperstimulation in the first cycle using only GnRHa. A 33-yr-old woman was referred to in vitro fertilization for oocyte donation. A depot preparation (3.75 mg) of tryptorelin without gonadotropins induced ovarian multifollicular enlargement with high estradiol level, and was followed by human chorionic gonadotropin administration and oocyte retrieval. In a subsequent cycle of the same patient, a low dose of tryptorelin (0.05 mg) did not induce ovarian hyperstimulation, and resulted in clinical pregnancy. This report shows potential management of ovarian hyperstimulation following the administration of GnRHa without gonadotropins.

    Original languageEnglish
    Pages (from-to)1394-1396
    Number of pages3
    JournalJournal of Korean medical science
    Volume26
    Issue number10
    DOIs
    Publication statusPublished - 2011 Oct

    Keywords

    • GnRH agonist
    • IVF
    • Ovarian hyperstimulation

    ASJC Scopus subject areas

    • Medicine(all)

    Fingerprint

    Dive into the research topics of 'Ovarian hyper-response to administration of an GnRH-Agonist without gonadotropins'. Together they form a unique fingerprint.

    Cite this