Gesamt- und ursachenspezifische Mortalität bei Riesenzellarteriitis: Eine Metaanalyse

Translated title of the contribution: Overall and cause-specific mortality in giant cell arteritis: A meta-analysis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: This study aimed to assess the all-cause and cause-specific standardized mortality ratios (SMRs) in patients with giant cell arteritis (GCA). Methods: We surveyed studies examining all-cause and/or cause-specific SMRs in patients with GCA compared to the general population, using MEDLINE, EMBASE, Cochrane databases, and manual searches. We then performed a meta-analysis of all-cause, sex-specific, region-specific, and cause-specific SMRs in patients with GCA. Results: In total, 8 reports including 1972 patients with GCA (including 877 patients who died) met the inclusion criteria. Compared with the general population, all-cause SMR was not increased in patients with GCA (SMR 1.081, 95% confidence interval [CI] 0.963–1.214, p?= 0.184). Stratification by region showed no significant increase in all-cause SMR in Europe and USA. Sex-specific meta-analysis revealed that the pooled SMR was 1.046 (95%CI 0.834–1.314, p?= 0.696) for women and 1.051 (95%CI 0.974–1.133, p?= 0.204) for men. There were no sex-specific significant differences in SMR. The risk of mortality due to cardiovascular disease (CVD) was significantly increased (SMR 1.312, 95%CI 1.136–1.516, p?< 0.001). However, there was no significant increase in the SMR for mortality due to cancer (SMR 0.833, 95%CI 0.613–1.132, p?= 0.243). Conclusions: Patients with GCA do not show increased rates of death from all causes, regardless of sex, region, or malignancy. However, these patients are at an increased risk of death due to CVD.

Original languageGerman
Pages (from-to)1-5
Number of pages5
JournalZeitschrift fur Rheumatologie
DOIs
Publication statusAccepted/In press - 2018 Mar 20

Fingerprint

Giant Cell Arteritis
Meta-Analysis
Mortality
Confidence Intervals
Cardiovascular Diseases
MEDLINE
Population

Keywords

  • GCA
  • Meta-analysis
  • Mortality

ASJC Scopus subject areas

  • Rheumatology

Cite this

@article{dc36e5602aaa4a24ae6e6ab37a29d788,
title = "Gesamt- und ursachenspezifische Mortalit{\"a}t bei Riesenzellarteriitis: Eine Metaanalyse",
abstract = "Objective: This study aimed to assess the all-cause and cause-specific standardized mortality ratios (SMRs) in patients with giant cell arteritis (GCA). Methods: We surveyed studies examining all-cause and/or cause-specific SMRs in patients with GCA compared to the general population, using MEDLINE, EMBASE, Cochrane databases, and manual searches. We then performed a meta-analysis of all-cause, sex-specific, region-specific, and cause-specific SMRs in patients with GCA. Results: In total, 8 reports including 1972 patients with GCA (including 877 patients who died) met the inclusion criteria. Compared with the general population, all-cause SMR was not increased in patients with GCA (SMR 1.081, 95{\%} confidence interval [CI] 0.963–1.214, p?= 0.184). Stratification by region showed no significant increase in all-cause SMR in Europe and USA. Sex-specific meta-analysis revealed that the pooled SMR was 1.046 (95{\%}CI 0.834–1.314, p?= 0.696) for women and 1.051 (95{\%}CI 0.974–1.133, p?= 0.204) for men. There were no sex-specific significant differences in SMR. The risk of mortality due to cardiovascular disease (CVD) was significantly increased (SMR 1.312, 95{\%}CI 1.136–1.516, p?< 0.001). However, there was no significant increase in the SMR for mortality due to cancer (SMR 0.833, 95{\%}CI 0.613–1.132, p?= 0.243). Conclusions: Patients with GCA do not show increased rates of death from all causes, regardless of sex, region, or malignancy. However, these patients are at an increased risk of death due to CVD.",
keywords = "GCA, Meta-analysis, Mortality",
author = "Lee, {Young Ho} and Song, {Gwan Gyu}",
year = "2018",
month = "3",
day = "20",
doi = "10.1007/s00393-018-0440-7",
language = "German",
pages = "1--5",
journal = "Zeitschrift fur Rheumatologie",
issn = "0340-1855",
publisher = "D. Steinkopff-Verlag",

}

TY - JOUR

T1 - Gesamt- und ursachenspezifische Mortalität bei Riesenzellarteriitis

T2 - Eine Metaanalyse

AU - Lee, Young Ho

AU - Song, Gwan Gyu

PY - 2018/3/20

Y1 - 2018/3/20

N2 - Objective: This study aimed to assess the all-cause and cause-specific standardized mortality ratios (SMRs) in patients with giant cell arteritis (GCA). Methods: We surveyed studies examining all-cause and/or cause-specific SMRs in patients with GCA compared to the general population, using MEDLINE, EMBASE, Cochrane databases, and manual searches. We then performed a meta-analysis of all-cause, sex-specific, region-specific, and cause-specific SMRs in patients with GCA. Results: In total, 8 reports including 1972 patients with GCA (including 877 patients who died) met the inclusion criteria. Compared with the general population, all-cause SMR was not increased in patients with GCA (SMR 1.081, 95% confidence interval [CI] 0.963–1.214, p?= 0.184). Stratification by region showed no significant increase in all-cause SMR in Europe and USA. Sex-specific meta-analysis revealed that the pooled SMR was 1.046 (95%CI 0.834–1.314, p?= 0.696) for women and 1.051 (95%CI 0.974–1.133, p?= 0.204) for men. There were no sex-specific significant differences in SMR. The risk of mortality due to cardiovascular disease (CVD) was significantly increased (SMR 1.312, 95%CI 1.136–1.516, p?< 0.001). However, there was no significant increase in the SMR for mortality due to cancer (SMR 0.833, 95%CI 0.613–1.132, p?= 0.243). Conclusions: Patients with GCA do not show increased rates of death from all causes, regardless of sex, region, or malignancy. However, these patients are at an increased risk of death due to CVD.

AB - Objective: This study aimed to assess the all-cause and cause-specific standardized mortality ratios (SMRs) in patients with giant cell arteritis (GCA). Methods: We surveyed studies examining all-cause and/or cause-specific SMRs in patients with GCA compared to the general population, using MEDLINE, EMBASE, Cochrane databases, and manual searches. We then performed a meta-analysis of all-cause, sex-specific, region-specific, and cause-specific SMRs in patients with GCA. Results: In total, 8 reports including 1972 patients with GCA (including 877 patients who died) met the inclusion criteria. Compared with the general population, all-cause SMR was not increased in patients with GCA (SMR 1.081, 95% confidence interval [CI] 0.963–1.214, p?= 0.184). Stratification by region showed no significant increase in all-cause SMR in Europe and USA. Sex-specific meta-analysis revealed that the pooled SMR was 1.046 (95%CI 0.834–1.314, p?= 0.696) for women and 1.051 (95%CI 0.974–1.133, p?= 0.204) for men. There were no sex-specific significant differences in SMR. The risk of mortality due to cardiovascular disease (CVD) was significantly increased (SMR 1.312, 95%CI 1.136–1.516, p?< 0.001). However, there was no significant increase in the SMR for mortality due to cancer (SMR 0.833, 95%CI 0.613–1.132, p?= 0.243). Conclusions: Patients with GCA do not show increased rates of death from all causes, regardless of sex, region, or malignancy. However, these patients are at an increased risk of death due to CVD.

KW - GCA

KW - Meta-analysis

KW - Mortality

UR - http://www.scopus.com/inward/record.url?scp=85046028982&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046028982&partnerID=8YFLogxK

U2 - 10.1007/s00393-018-0440-7

DO - 10.1007/s00393-018-0440-7

M3 - Article

C2 - 29557499

AN - SCOPUS:85046028982

SP - 1

EP - 5

JO - Zeitschrift fur Rheumatologie

JF - Zeitschrift fur Rheumatologie

SN - 0340-1855

ER -