Overall rate, location, and predictive factors for positive surgical margins after robot-assisted laparoscopic radical prostatectomy for high-risk prostate cancer

Sung-Gu Kang, Oscar Schatloff, Abdul Muhsin Haidar, Srinivas Samavedi, Kenneth J. Palmer, Jun Cheon, Vipul R. Patel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We report the overall rate, locations and predictive factors of positive surgical margins (PSMs) in 271 patients with high-risk prostate cancer. Between April 2008 and October 2011, we prospectively collected data from patients classified as D'Amico high-risk who underwent robot-assisted laparoscopic radical prostatectomy. Overall rate and location of PSMs were reported. Stepwise logistic regression models were fitted to assess predictive factors of PSM. The overall rate of PSMs was 25.1% (68 of 271 patients). Of these PSM, 38.2% (26 of 68) were posterolateral (PL), 26.5% (18 of 68) multifocal, 16.2% (11 of 68) in the apex, 14.7% (10 of 68) in the bladder neck, and 4.4% (3/68) in other locations. The PSM rate of patients with pathological stage pT2 was 8.6% (12 of 140), 26.6% (17 of 64) of pT3a, 53.3% (32/60) of pT3b, and 100% (7 of 7) of pT4. In a logistic regression model including pre-, intra-, and post-operative parameters, body mass index (odds ratio [OR]: 1.09; 95% confidence interval [CI]: 1.01-1.19, P= 0.029), pathological stage (pT3b or higher vs pT2; OR: 5.14; 95% CI: 1.92-13.78; P = 0.001) and percentage of the tumor (OR: 46.71; 95% CI: 6.37-342.57; P< 0.001) were independent predictive factors for PSMs. The most common location of PSMs in patients at high-risk was the PL aspect, which reflects the reported tumor aggressiveness. The only significant predictive factors of PSMs were pathological outcomes, such as percentage of the tumor in the specimen and pathological stage.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalAsian Journal of Andrology
Volume18
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

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Prostatectomy
Prostatic Neoplasms
Logistic Models
Odds Ratio
Confidence Intervals
Margins of Excision
Neoplasms
Urinary Bladder
Body Mass Index

Keywords

  • Prostate
  • Prostatectomy
  • Prostatic neoplasm
  • Residual
  • Robotics

ASJC Scopus subject areas

  • Urology

Cite this

Overall rate, location, and predictive factors for positive surgical margins after robot-assisted laparoscopic radical prostatectomy for high-risk prostate cancer. / Kang, Sung-Gu; Schatloff, Oscar; Haidar, Abdul Muhsin; Samavedi, Srinivas; Palmer, Kenneth J.; Cheon, Jun; Patel, Vipul R.

In: Asian Journal of Andrology, Vol. 18, No. 1, 01.01.2016, p. 123-128.

Research output: Contribution to journalArticle

Kang, Sung-Gu ; Schatloff, Oscar ; Haidar, Abdul Muhsin ; Samavedi, Srinivas ; Palmer, Kenneth J. ; Cheon, Jun ; Patel, Vipul R. / Overall rate, location, and predictive factors for positive surgical margins after robot-assisted laparoscopic radical prostatectomy for high-risk prostate cancer. In: Asian Journal of Andrology. 2016 ; Vol. 18, No. 1. pp. 123-128.
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AB - We report the overall rate, locations and predictive factors of positive surgical margins (PSMs) in 271 patients with high-risk prostate cancer. Between April 2008 and October 2011, we prospectively collected data from patients classified as D'Amico high-risk who underwent robot-assisted laparoscopic radical prostatectomy. Overall rate and location of PSMs were reported. Stepwise logistic regression models were fitted to assess predictive factors of PSM. The overall rate of PSMs was 25.1% (68 of 271 patients). Of these PSM, 38.2% (26 of 68) were posterolateral (PL), 26.5% (18 of 68) multifocal, 16.2% (11 of 68) in the apex, 14.7% (10 of 68) in the bladder neck, and 4.4% (3/68) in other locations. The PSM rate of patients with pathological stage pT2 was 8.6% (12 of 140), 26.6% (17 of 64) of pT3a, 53.3% (32/60) of pT3b, and 100% (7 of 7) of pT4. In a logistic regression model including pre-, intra-, and post-operative parameters, body mass index (odds ratio [OR]: 1.09; 95% confidence interval [CI]: 1.01-1.19, P= 0.029), pathological stage (pT3b or higher vs pT2; OR: 5.14; 95% CI: 1.92-13.78; P = 0.001) and percentage of the tumor (OR: 46.71; 95% CI: 6.37-342.57; P< 0.001) were independent predictive factors for PSMs. The most common location of PSMs in patients at high-risk was the PL aspect, which reflects the reported tumor aggressiveness. The only significant predictive factors of PSMs were pathological outcomes, such as percentage of the tumor in the specimen and pathological stage.

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