Overexpression of an elongation factor-1γ-hybridizing RNA in colorectal adenomas

B. Ender, P. Lynch, Yeul Hong Kim, N. V. Inamdar, K. R. Cleary, M. L. Frazier

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23 Citations (Scopus)

Abstract

While it is apparent that colorectal carcinogenesis results from a series of genetic alterations manifested phenotypically by the adenoma-to-carcinoma squence, the early events that occur in the process of tumorigenesis have not been elucidated. We previously demonstrated that human elongation factor-1 (EF-1)γ-hybridizing RNA was overexpressed in 25 of 29 colorectal carcinomas. To determine if the overexpression of this mRNA occurs early in tumor development, we examined 25 adenomas and corresponding normal-appearing distant mucosae from 20 patients without familial adenomatous polyposis (FAP). We observed overexpression at a level of twofold or more in 14 (56%) of the 25 adenomas, indicating that overexpression of EF-1γ RNA is often a relatively early event in the development of non-FAP colorectal cancer.

Original languageEnglish
Pages (from-to)18-20
Number of pages3
JournalMolecular Carcinogenesis
Volume7
Issue number1
DOIs
Publication statusPublished - 1993 Feb 24
Externally publishedYes

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Keywords

  • Adenoma
  • Colorectal cancer
  • Elongation factor-1

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology

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