Overhydration negatively affects quality of life in peritoneal dialysis patients: Evidence from a prospective observational study

The Quality of Life of Dialysis Patients (QOLD) Study Group

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16 Citations (Scopus)


Backgound: This study evaluated whether the hydration status affected health-related quality of life (HRQOL) during 12 months in peritoneal dialysis (PD) patients. Methods: The hydration status and the HRQOL were examined at baseline and after 12 months using a bioimpedance spectroscopy and Kidney Disease Quality of Life-Short Form, respectively in PD patients. Four hundred eighty-one patients were included and divided according to the baseline overhydration (OH) value; normohydration group (NH group, -2L≤ OH ≤+2L, n=266) and overhydration group (OH group, OH >+2L, n=215). Baseline HRQOL scores were compared between the two groups. The subjects were re-stratified into quartiles according to the OH difference (OH value at baseline – OH value at 12 months; <-1, -1 – -0.1, -0.1 – +1, and ≥+1L). The relations of OH difference with HRQOL scores at 12 months and the association of OH difference with the HRQOL score difference (HRQOL score at baseline – HRQOL score at 12 months) were assessed. Results: The OH group showed significantly lower baseline physical and mental health scores (PCS and MCS), and kidney disease component scores (KDCS) compared with the NH group (all, P<0.01). At 12 months, the adjusted PCS, MCS, and KDCS significantly increased as the OH difference quartiles increased (P<0.001, P=0.002, P<0.001, respectively). In multivariate analysis, the OH difference was independently associated with higher PCS (β = 2.04, P< .001), MCS (β=1.02, P=0.002), and KDCS (β=1.06, P<0.001) at 12 months. The OH difference was independently associated with the PCS difference (β = -1.81, P<0.001), MCS difference (β=-0.92, P=0.01), and KDCS difference (β=-0.90, P=0.001). Conclusion: The hydration status was associated with HRQOL and increased hydration status negatively affected HRQOL after 12 months in PD patients.

Original languageEnglish
Pages (from-to)683-695
Number of pages13
JournalInternational Journal of Medical Sciences
Issue number9
Publication statusPublished - 2016 Aug 11
Externally publishedYes


  • Bioimpedance
  • Fluid overload
  • Overhydration
  • Peritoneal dialysis
  • Quality of life

ASJC Scopus subject areas

  • Medicine(all)


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