Overview of the Korean longitudinal study on cognitive aging and dementia

Ji Won Han, Tae Hui Kim, Kyung Phil Kwak, Kayoung Kim, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hyun Kim, Seok Woo Moon, Jae Young Park, Joon Hyuk Park, Seonjeong Byun, Seung Wan Suh, Ji Young Seo, Yoonseop So, Seung Ho Ryu, Jong Chul Youn, Kyoung Hwan Lee, Dong Young Lee, Dong Woo LeeSeok Bum Lee, Jung Jae Lee, Ju Ri Lee, Hyeon Jeong, Hyun-Ghang Jeong, Jin Hyeong Jhoo, Kyuhee Han, Jong Woo Hong, Ki Woong Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)


Objective Due to an unprecedented rate of population aging, South Korea is facing a dementia epidemic. For this reason, the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) was launched in 2009 with support from the Korean Health Industry Development Institute to investigate the epidemiology, biopsychosocial risk factors, and outcomes of dementia and dementia-related conditions. Methods The KLOSCAD is the first nationwide multi-center population-based prospective cohort study. In October 2010, 12,694 individuals were randomly sampled from residents aged 60 years or older who lived in 13 districts across South Korea. In the baseline assessment, which was conducted from November 2010 through October 2012, 6,818 (53.7%) individuals participated. Follow-up assessments have been conducted every two years, with the first follow-up assessment conducted between November 2012 and October 2014, and the second between November 2014 and October 2016. The third is now in progress, and will span from November 2016 to October 2018. Diagnosis of cognitive disorders, neuropsychological battery, behavioral and psychological symptoms of dementia, activities of daily living, physical and neurologic examination and laboratory tests, life styles, quality of life, and identification of death were evaluated in each assessment. Results The cumulative drop-out rate at the second follow-up assessment was 38.7%. Dementia and mild cognitive impairment were 5.0% and 27.0%, respectively. Conclusion The KLOSCAD may provide strong scientific evidence for advancing the fight against dementia both in Korea and globally.

Original languageEnglish
Pages (from-to)767-774
Number of pages8
JournalPsychiatry Investigation
Issue number8
Publication statusPublished - 2018 Aug 1


  • Cognitive ageing
  • Cohort study
  • Community
  • Dementia
  • Korea
  • Longitudinal
  • Mild cognitive impairment
  • Multicenter
  • Prospective

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Han, J. W., Kim, T. H., Kwak, K. P., Kim, K., Kim, B. J., Kim, S. G., Kim, J. L., Kim, T. H., Moon, S. W., Park, J. Y., Park, J. H., Byun, S., Suh, S. W., Seo, J. Y., So, Y., Ryu, S. H., Youn, J. C., Lee, K. H., Lee, D. Y., ... Kim, K. W. (2018). Overview of the Korean longitudinal study on cognitive aging and dementia. Psychiatry Investigation, 15(8), 767-774. https://doi.org/10.30773/pi.2018.06.02