Overweight, hypertension and renal dysfunction in adulthood of neonatally overfed rats

Hyung Eun Yim, Kee Soo Ha, In Sun Bae, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)


    Accelerated growth in early infancy has been associated with later cardiovascular and metabolic diseases. We investigated the influence of overnutrition during neonatal periods on the development of renal pathophysiological changes in adult offspring rats. Three or 10 male pups per mother were assigned to either the small litter (SL) or normal litter (NL) control groups during the first 21 days of life. The effects of early postnatal overnutrition on body weight, blood pressure and renal changes were determined at 3 and 6 months. Pups in the SL group weighed more than controls between 7 days and 6 months of age (P<.05). In the SL group, serum creatinine levels were higher at 3 and 6 months (P<.05), and at 6 months, blood pressure levels were higher than those of the controls (P<.05). The number of ED-1 positive macrophages in renal cortex and glomerulosclerosis index increased in the SL group at 3 and 6 months (P<.05). Additionally, cortical apoptotic cells increased in the SL group at 6 months (P<.05). Immunoblotting and immunohistochemistry showed that matrix metalloproteinase (MMP)-9 protein expressions decreased and tissue inhibitor of MMP-1, tumor necrosis factor-α, osteopontin and adiponectin expressions increased in the SL group at 3 months (P<.05). However, at 6 months, MMP-9 expression was elevated, and osteopontin expression remained elevated in the SL group (P<.05). Early postnatal overfeeding can lead to lasting overweight, hypertension and renal dysfunction and place a greater burden on the kidney.

    Original languageEnglish
    Pages (from-to)1324-1333
    Number of pages10
    JournalJournal of Nutritional Biochemistry
    Issue number7
    Publication statusPublished - 2013 Jul


    • Chronic renal insufficiency
    • Hypertension
    • Obesity
    • Overnutrition
    • Postnatal growth

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Biochemistry
    • Molecular Biology
    • Nutrition and Dietetics
    • Clinical Biochemistry


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