Abstract
Chitosan was modified by coupling with linoleic acid through the 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide-mediated reaction to increase its amphipathicity for improved emulsification. The micelle formation of linoleic acid-modified chitosan in the 0.1 M acetic acid solution was enhanced by O/W emulsification with methylene chloride, an oil phase. The fluorescence spectra indicate that without emulsification the self-aggregation of LA-chitosan occurred at the concentration of 1.0 g/L or above, and with emulsification, selfaggregation was greatly enhanced followed by a stable micelle formation at 2.0 g/L. The addition of 1 M sodium chloride promoted the self-aggregation of LA-chitosan molecules both with and without emulsification. The micelles of LA-chitosan formed nanosize particles ranging from 200 to 600 nm. The LA-chitosan nanoparticles encapsulated the lipid soluble model compound, retinal acetate, with 50% efficiency.
Original language | English |
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Pages (from-to) | 3135-3139 |
Number of pages | 5 |
Journal | Journal of agricultural and food chemistry |
Volume | 51 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2003 May 7 |
Keywords
- Chemical modification
- Chitosan
- Emulsification
- Encapsulation
- Linoleic acid
- Micelles
- Nanoparticle
ASJC Scopus subject areas
- Chemistry(all)
- Agricultural and Biological Sciences(all)