O/W emulsification for the self-aggregation and nanoparticle formation of linoleic acid-modified chitosan in the aqueous system

Xi Guang Chen, Chong M. Lee, Hyun Jin Park

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

Chitosan was modified by coupling with linoleic acid through the 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide-mediated reaction to increase its amphipathicity for improved emulsification. The micelle formation of linoleic acid-modified chitosan in the 0.1 M acetic acid solution was enhanced by O/W emulsification with methylene chloride, an oil phase. The fluorescence spectra indicate that without emulsification the self-aggregation of LA-chitosan occurred at the concentration of 1.0 g/L or above, and with emulsification, selfaggregation was greatly enhanced followed by a stable micelle formation at 2.0 g/L. The addition of 1 M sodium chloride promoted the self-aggregation of LA-chitosan molecules both with and without emulsification. The micelles of LA-chitosan formed nanosize particles ranging from 200 to 600 nm. The LA-chitosan nanoparticles encapsulated the lipid soluble model compound, retinal acetate, with 50% efficiency.

Original languageEnglish
Pages (from-to)3135-3139
Number of pages5
JournalJournal of Agricultural and Food Chemistry
Volume51
Issue number10
DOIs
Publication statusPublished - 2003 May 7

Keywords

  • Chemical modification
  • Chitosan
  • Emulsification
  • Encapsulation
  • Linoleic acid
  • Micelles
  • Nanoparticle

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Chemistry (miscellaneous)

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