Oxidative stabilization of conjugated linoleic acid by one-pot pegylation

Hyun-Seuk Moon, Ji Hye Seo, Ding Ding Guo, Hong Gu Lee, Prati Bajracharya, Yun Jaie Choi, Keunsoo Jeong, Chong Rae Park, Chong Su Cho

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Abstract

This study describes a novel and one-step procedure for the PEGylation of conjugated linoleic acid (CLA) in the melting state without solvents or catalysts for oxidative stabilization of CLA. The double bonds of CLA in PEGylated CLA (PCLA) were clearly detected by 1H NMR (nuclear magnetic resonance) spectroscopy, indicating the successful PEGylation of CLA without oxidation during PEGylation, even at high temperatures. The level of headspace oxygen depletion by PCLA was lower than CLA, indicating that the oxidation of CLA was protected by PEGylation. This easy and simple one-pot PEGylation of CLA is an effective way of preparing fatty acids with increased stability to oxidation, which would be quite useful for nutritional and pharmaceutical studies.

Original languageEnglish
Pages (from-to)822-826
Number of pages5
JournalMacromolecular Research
Volume19
Issue number8
DOIs
Publication statusPublished - 2011 Aug 1
Externally publishedYes

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Keywords

  • Conjugated linoleic acid
  • Oxidative stability
  • PEGylation
  • Poly(ethylene glycol)

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics
  • Chemical Engineering(all)

Cite this

Moon, H-S., Seo, J. H., Guo, D. D., Lee, H. G., Bajracharya, P., Choi, Y. J., Jeong, K., Park, C. R., & Cho, C. S. (2011). Oxidative stabilization of conjugated linoleic acid by one-pot pegylation. Macromolecular Research, 19(8), 822-826. https://doi.org/10.1007/s13233-011-0803-2