Oxidative stabilization of conjugated linoleic acid by one-pot pegylation

Hyun Seuk Moon; Ji Hye Seo; Ding Ding Guo; Hong Gu Lee; Prati Bajracharya; Yun Jaie Choi; Keunsoo Jeong; Chong Rae Park; Chong Su Cho

doi:10.1007/s13233-011-0803-2

Oxidative stabilization of conjugated linoleic acid by one-pot pegylation

Hyun Seuk Moon, Ji Hye Seo, Ding Ding Guo, Hong Gu Lee, Prati Bajracharya, Yun Jaie Choi, Keunsoo Jeong, Chong Rae Park, Chong Su Cho

Division of Biotechnology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

This study describes a novel and one-step procedure for the PEGylation of conjugated linoleic acid (CLA) in the melting state without solvents or catalysts for oxidative stabilization of CLA. The double bonds of CLA in PEGylated CLA (PCLA) were clearly detected by 1H NMR (nuclear magnetic resonance) spectroscopy, indicating the successful PEGylation of CLA without oxidation during PEGylation, even at high temperatures. The level of headspace oxygen depletion by PCLA was lower than CLA, indicating that the oxidation of CLA was protected by PEGylation. This easy and simple one-pot PEGylation of CLA is an effective way of preparing fatty acids with increased stability to oxidation, which would be quite useful for nutritional and pharmaceutical studies.

Original language	English
Pages (from-to)	822-826
Number of pages	5
Journal	Macromolecular Research
Volume	19
Issue number	8
DOIs	https://doi.org/10.1007/s13233-011-0803-2
Publication status	Published - 2011 Aug

Keywords

Conjugated linoleic acid
Oxidative stability
PEGylation
Poly(ethylene glycol)

ASJC Scopus subject areas

Chemical Engineering(all)
Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1007/s13233-011-0803-2

Cite this

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title = "Oxidative stabilization of conjugated linoleic acid by one-pot pegylation",

abstract = "This study describes a novel and one-step procedure for the PEGylation of conjugated linoleic acid (CLA) in the melting state without solvents or catalysts for oxidative stabilization of CLA. The double bonds of CLA in PEGylated CLA (PCLA) were clearly detected by 1H NMR (nuclear magnetic resonance) spectroscopy, indicating the successful PEGylation of CLA without oxidation during PEGylation, even at high temperatures. The level of headspace oxygen depletion by PCLA was lower than CLA, indicating that the oxidation of CLA was protected by PEGylation. This easy and simple one-pot PEGylation of CLA is an effective way of preparing fatty acids with increased stability to oxidation, which would be quite useful for nutritional and pharmaceutical studies.",

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journal = "Macromolecular Research",

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AU - Moon, Hyun Seuk

AU - Seo, Ji Hye

AU - Guo, Ding Ding

AU - Lee, Hong Gu

AU - Bajracharya, Prati

AU - Choi, Yun Jaie

AU - Jeong, Keunsoo

AU - Park, Chong Rae

AU - Cho, Chong Su

PY - 2011/8

Y1 - 2011/8

N2 - This study describes a novel and one-step procedure for the PEGylation of conjugated linoleic acid (CLA) in the melting state without solvents or catalysts for oxidative stabilization of CLA. The double bonds of CLA in PEGylated CLA (PCLA) were clearly detected by 1H NMR (nuclear magnetic resonance) spectroscopy, indicating the successful PEGylation of CLA without oxidation during PEGylation, even at high temperatures. The level of headspace oxygen depletion by PCLA was lower than CLA, indicating that the oxidation of CLA was protected by PEGylation. This easy and simple one-pot PEGylation of CLA is an effective way of preparing fatty acids with increased stability to oxidation, which would be quite useful for nutritional and pharmaceutical studies.

AB - This study describes a novel and one-step procedure for the PEGylation of conjugated linoleic acid (CLA) in the melting state without solvents or catalysts for oxidative stabilization of CLA. The double bonds of CLA in PEGylated CLA (PCLA) were clearly detected by 1H NMR (nuclear magnetic resonance) spectroscopy, indicating the successful PEGylation of CLA without oxidation during PEGylation, even at high temperatures. The level of headspace oxygen depletion by PCLA was lower than CLA, indicating that the oxidation of CLA was protected by PEGylation. This easy and simple one-pot PEGylation of CLA is an effective way of preparing fatty acids with increased stability to oxidation, which would be quite useful for nutritional and pharmaceutical studies.

KW - Conjugated linoleic acid

KW - Oxidative stability

KW - PEGylation

KW - Poly(ethylene glycol)

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Oxidative stabilization of conjugated linoleic acid by one-pot pegylation

Abstract

Keywords

ASJC Scopus subject areas

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