Oxidative stabilization of conjugated linoleic acid by one-pot pegylation

Hyun-Seuk Moon, Ji Hye Seo, Ding Ding Guo, Hong Gu Lee, Prati Bajracharya, Yun Jaie Choi, Keunsoo Jeong, Chong Rae Park, Chong Su Cho

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This study describes a novel and one-step procedure for the PEGylation of conjugated linoleic acid (CLA) in the melting state without solvents or catalysts for oxidative stabilization of CLA. The double bonds of CLA in PEGylated CLA (PCLA) were clearly detected by 1H NMR (nuclear magnetic resonance) spectroscopy, indicating the successful PEGylation of CLA without oxidation during PEGylation, even at high temperatures. The level of headspace oxygen depletion by PCLA was lower than CLA, indicating that the oxidation of CLA was protected by PEGylation. This easy and simple one-pot PEGylation of CLA is an effective way of preparing fatty acids with increased stability to oxidation, which would be quite useful for nutritional and pharmaceutical studies.

Original languageEnglish
Pages (from-to)822-826
Number of pages5
JournalMacromolecular Research
Volume19
Issue number8
DOIs
Publication statusPublished - 2011 Aug 1
Externally publishedYes

Fingerprint

Linoleic acid
Conjugated Linoleic Acids
Stabilization
Oxidation
Fatty acids
Drug products
Nuclear magnetic resonance spectroscopy
Melting
Fatty Acids
Oxygen
Catalysts

Keywords

  • Conjugated linoleic acid
  • Oxidative stability
  • PEGylation
  • Poly(ethylene glycol)

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics
  • Chemical Engineering(all)

Cite this

Moon, H-S., Seo, J. H., Guo, D. D., Lee, H. G., Bajracharya, P., Choi, Y. J., ... Cho, C. S. (2011). Oxidative stabilization of conjugated linoleic acid by one-pot pegylation. Macromolecular Research, 19(8), 822-826. https://doi.org/10.1007/s13233-011-0803-2

Oxidative stabilization of conjugated linoleic acid by one-pot pegylation. / Moon, Hyun-Seuk; Seo, Ji Hye; Guo, Ding Ding; Lee, Hong Gu; Bajracharya, Prati; Choi, Yun Jaie; Jeong, Keunsoo; Park, Chong Rae; Cho, Chong Su.

In: Macromolecular Research, Vol. 19, No. 8, 01.08.2011, p. 822-826.

Research output: Contribution to journalArticle

Moon, H-S, Seo, JH, Guo, DD, Lee, HG, Bajracharya, P, Choi, YJ, Jeong, K, Park, CR & Cho, CS 2011, 'Oxidative stabilization of conjugated linoleic acid by one-pot pegylation', Macromolecular Research, vol. 19, no. 8, pp. 822-826. https://doi.org/10.1007/s13233-011-0803-2
Moon, Hyun-Seuk ; Seo, Ji Hye ; Guo, Ding Ding ; Lee, Hong Gu ; Bajracharya, Prati ; Choi, Yun Jaie ; Jeong, Keunsoo ; Park, Chong Rae ; Cho, Chong Su. / Oxidative stabilization of conjugated linoleic acid by one-pot pegylation. In: Macromolecular Research. 2011 ; Vol. 19, No. 8. pp. 822-826.
@article{d6d7f59d5aa344948bf9205a3460768f,
title = "Oxidative stabilization of conjugated linoleic acid by one-pot pegylation",
abstract = "This study describes a novel and one-step procedure for the PEGylation of conjugated linoleic acid (CLA) in the melting state without solvents or catalysts for oxidative stabilization of CLA. The double bonds of CLA in PEGylated CLA (PCLA) were clearly detected by 1H NMR (nuclear magnetic resonance) spectroscopy, indicating the successful PEGylation of CLA without oxidation during PEGylation, even at high temperatures. The level of headspace oxygen depletion by PCLA was lower than CLA, indicating that the oxidation of CLA was protected by PEGylation. This easy and simple one-pot PEGylation of CLA is an effective way of preparing fatty acids with increased stability to oxidation, which would be quite useful for nutritional and pharmaceutical studies.",
keywords = "Conjugated linoleic acid, Oxidative stability, PEGylation, Poly(ethylene glycol)",
author = "Hyun-Seuk Moon and Seo, {Ji Hye} and Guo, {Ding Ding} and Lee, {Hong Gu} and Prati Bajracharya and Choi, {Yun Jaie} and Keunsoo Jeong and Park, {Chong Rae} and Cho, {Chong Su}",
year = "2011",
month = "8",
day = "1",
doi = "10.1007/s13233-011-0803-2",
language = "English",
volume = "19",
pages = "822--826",
journal = "Macromolecular Research",
issn = "1598-5032",
publisher = "Polymer Society of Korea",
number = "8",

}

TY - JOUR

T1 - Oxidative stabilization of conjugated linoleic acid by one-pot pegylation

AU - Moon, Hyun-Seuk

AU - Seo, Ji Hye

AU - Guo, Ding Ding

AU - Lee, Hong Gu

AU - Bajracharya, Prati

AU - Choi, Yun Jaie

AU - Jeong, Keunsoo

AU - Park, Chong Rae

AU - Cho, Chong Su

PY - 2011/8/1

Y1 - 2011/8/1

N2 - This study describes a novel and one-step procedure for the PEGylation of conjugated linoleic acid (CLA) in the melting state without solvents or catalysts for oxidative stabilization of CLA. The double bonds of CLA in PEGylated CLA (PCLA) were clearly detected by 1H NMR (nuclear magnetic resonance) spectroscopy, indicating the successful PEGylation of CLA without oxidation during PEGylation, even at high temperatures. The level of headspace oxygen depletion by PCLA was lower than CLA, indicating that the oxidation of CLA was protected by PEGylation. This easy and simple one-pot PEGylation of CLA is an effective way of preparing fatty acids with increased stability to oxidation, which would be quite useful for nutritional and pharmaceutical studies.

AB - This study describes a novel and one-step procedure for the PEGylation of conjugated linoleic acid (CLA) in the melting state without solvents or catalysts for oxidative stabilization of CLA. The double bonds of CLA in PEGylated CLA (PCLA) were clearly detected by 1H NMR (nuclear magnetic resonance) spectroscopy, indicating the successful PEGylation of CLA without oxidation during PEGylation, even at high temperatures. The level of headspace oxygen depletion by PCLA was lower than CLA, indicating that the oxidation of CLA was protected by PEGylation. This easy and simple one-pot PEGylation of CLA is an effective way of preparing fatty acids with increased stability to oxidation, which would be quite useful for nutritional and pharmaceutical studies.

KW - Conjugated linoleic acid

KW - Oxidative stability

KW - PEGylation

KW - Poly(ethylene glycol)

UR - http://www.scopus.com/inward/record.url?scp=80052624771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052624771&partnerID=8YFLogxK

U2 - 10.1007/s13233-011-0803-2

DO - 10.1007/s13233-011-0803-2

M3 - Article

AN - SCOPUS:80052624771

VL - 19

SP - 822

EP - 826

JO - Macromolecular Research

JF - Macromolecular Research

SN - 1598-5032

IS - 8

ER -