Oxidative/nitrosative stress and antidepressants: Targets for novel antidepressants

Seung Yup Lee, Soo Jung Lee, Changsu Han, Ashwin A. Patkar, Prakash S. Masand, Chi Un Pae

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

The brain is an organ predisposed to oxidative/nitrosative stress. This is especially true in the case of aging as well as several neurodegenerative diseases. Under such circumstances, a decline in the normal antioxidant defense mechanisms leads to an increase in the vulnerability of the brain to the deleterious effects of oxidative damage. Highly reactive oxygen/nitrogen species damage lipids, proteins, and mitochondrial and neuronal genes. Unless antioxidant defenses react appropriately to damage inflicted by radicals, neurons may experience microalteration, microdysfunction, and degeneration. We reviewed how oxidative and nitrosative stresses contribute to the pathogenesis of depressive disorders and reviewed the clinical implications of various antioxidants as future targets for antidepressant treatment.

Original languageEnglish
Pages (from-to)224-235
Number of pages12
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume46
DOIs
Publication statusPublished - 2013 Oct 1

Keywords

  • Antidepressant
  • Depression
  • Novel target
  • Oxidative/nitrosative stress

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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