Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium-CaMKK-AMPK pathway

Eun Soo Lee, Kyung Ok Uhm, Yun Mi Lee, Joseph Kwon, Sun Hwa Park, Kim Hyeon Soo

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Oxytocin is a mammalian hormone that is released mainly after distension of the uterine cervix. In this study, we report that oxytocin stimulates intracellular release of calcium, and also activates AMPK (AMP-activated protein kinase) in C2C12 myoblast cells in a time/dose-dependent manner. Oxytocin receptor mRNA was detected in C2C12 cells. In addition, oxytocin stimulated glucose uptake and, moreover, inhibition of either CaMKK (Ca2+/calmodulin-dependent protein kinase kinase) or AMPK blocked oxytocin-mediated AMPK activation and glucose uptake. Taken together, our findings suggest that oxytocin may serve a peripheral metabolic function in skeletal muscle cells through the calcium-CaMKK-AMPK pathway.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalRegulatory Peptides
Volume151
Issue number1-3
DOIs
Publication statusPublished - 2008 Nov 29

Keywords

  • ACC
  • AMPK
  • CaMKK
  • Calcium
  • Oxytocin

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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