P19 Embryonal carcinoma cells: A new model for the study of endothelial cell differentiation

Seung Cheol Choi, Ji Hyun Choi, Wan Joo Shim, Do Sun Lim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

P19 embryonal carcinoma cells were examined under different conditions of embryoid body (EB) formation to evaluate endothelial differentiation. A prominent capillary-like network including PECAM-1 positive cells and upregulated expression of endothelial markers Tie-1, Tie-2, Flk-1 and PECAM-1 were identified in the DMSO-treated group during EB formation as well as after VEGF treatment. About 4% of the P19 cells differentiated into PECAM-1 positive cells on day 14 of differentiation. These results suggest that the P19 cells have the potential for endothelial cell differentiation and provide a new model system for future research.

Original languageEnglish
Pages (from-to)1169-1175
Number of pages7
JournalBiotechnology letters
Volume30
Issue number7
DOIs
Publication statusPublished - 2008 Jul

Keywords

  • Carcinoma cells
  • Dimethyl sulphoxide
  • Embryoid body
  • Endothelial cell differentiation
  • P19 embryonal carcinoma cells
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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