Packing of metalized polymer nanofibers for aneurysm embolization

Min Woo Kim, Seongpil An, Karam Kim, Tae Gun Kim, Hong Seok Jo, Dong-Hyuk Park, Suk Goo Yoon, Alexander Yarin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aneurysmal subarachnoid hemorrhage (SAH) is the extravasation of blood into the subarachnoid space and is fatal in most cases. Platinum coils have been used to fill the hemorrhage site and prevent the extravasation of blood. Here we explored the use of Pt-coated polymer nanofibers (NF) to prevent blood extravasation and were able to achieve improved results in vitro. The polymer nanofibers were produced via electrospinning and were subsequently electroplated with Pt, resulting in metalized nanofibers. These nanofibers were installed within a microfluidic channel, and the resulting reduction in the permeability was evaluated using a fluid similar to blood. Based on the obtained results, these newly developed nanofibers are expected to decrease the operation cost for SAH, owing to their reduced size and low material cost. Furthermore, it is expected that these nanofibers will be used in a smaller amount during SAH operation while having the same preventive effect. This should reduce the operational risk associated with the multiple steps required to place the Pt coils at the SAH site. Finally, the underlying hydrodynamic mechanism responsible for the reduced permeability of the synthesized nanofibers is described.

Original languageEnglish
Pages (from-to)6589-6601
Number of pages13
JournalNanoscale
Volume10
Issue number14
DOIs
Publication statusPublished - 2018 Apr 14

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Nanofibers
Polymers
Blood
Electrospinning
Platinum
Microfluidics
Costs
Hydrodynamics
Fluids

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Kim, M. W., An, S., Kim, K., Kim, T. G., Jo, H. S., Park, D-H., ... Yarin, A. (2018). Packing of metalized polymer nanofibers for aneurysm embolization. Nanoscale, 10(14), 6589-6601. https://doi.org/10.1039/c7nr09645c

Packing of metalized polymer nanofibers for aneurysm embolization. / Kim, Min Woo; An, Seongpil; Kim, Karam; Kim, Tae Gun; Jo, Hong Seok; Park, Dong-Hyuk; Yoon, Suk Goo; Yarin, Alexander.

In: Nanoscale, Vol. 10, No. 14, 14.04.2018, p. 6589-6601.

Research output: Contribution to journalArticle

Kim, MW, An, S, Kim, K, Kim, TG, Jo, HS, Park, D-H, Yoon, SG & Yarin, A 2018, 'Packing of metalized polymer nanofibers for aneurysm embolization', Nanoscale, vol. 10, no. 14, pp. 6589-6601. https://doi.org/10.1039/c7nr09645c
Kim, Min Woo ; An, Seongpil ; Kim, Karam ; Kim, Tae Gun ; Jo, Hong Seok ; Park, Dong-Hyuk ; Yoon, Suk Goo ; Yarin, Alexander. / Packing of metalized polymer nanofibers for aneurysm embolization. In: Nanoscale. 2018 ; Vol. 10, No. 14. pp. 6589-6601.
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