Pain and depression: A neurobiological perspective of their relationship

Changsu Han, Chi Un Pae

    Research output: Contribution to journalArticlepeer-review

    48 Citations (Scopus)


    Remarkable progresses have been achieved regarding the understanding of the neurobiological bases of pain and depression. The principal role of neurotransmitters, neuromodulators, and neurohormones has been proposed in the development of pain and depression. With the progression of molecular biology, an intricate interaction among biological factors accountable to the development and management of pain and depression has been also shown in a numerous preclinical and clinical researches. This mini-review will briefly describe the current issues and future research direction for better understanding of the relationship between pain and depression.

    Original languageEnglish
    Pages (from-to)1-8
    Number of pages8
    JournalPsychiatry Investigation
    Issue number1
    Publication statusPublished - 2015 Jan 1


    • Aa Depression
    • Pain
    • Pathophysiology
    • Relationship
    • Symptomatology
    • Treatment

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Biological Psychiatry


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