Pain and depression: A neurobiological perspective of their relationship

Changsu Han, Chi Un Pae

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)


Remarkable progresses have been achieved regarding the understanding of the neurobiological bases of pain and depression. The principal role of neurotransmitters, neuromodulators, and neurohormones has been proposed in the development of pain and depression. With the progression of molecular biology, an intricate interaction among biological factors accountable to the development and management of pain and depression has been also shown in a numerous preclinical and clinical researches. This mini-review will briefly describe the current issues and future research direction for better understanding of the relationship between pain and depression.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalPsychiatry Investigation
Issue number1
Publication statusPublished - 2015 Jan 1
Externally publishedYes


  • Aa Depression
  • Pain
  • Pathophysiology
  • Relationship
  • Symptomatology
  • Treatment

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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