Palladium-Catalyzed Decarboxylative Coupling Reactions of Propiolic Acid Derivatives and Arylsulfonyl Hydrazide

Jaerim Park; Kwang Ho Song; Sunwoo Lee

doi:10.1055/s-0036-1591596

Palladium-Catalyzed Decarboxylative Coupling Reactions of Propiolic Acid Derivatives and Arylsulfonyl Hydrazide

Jaerim Park, Kwang Ho Song, Sunwoo Lee

Department of Chemical and Biological Engineering

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Arylsulfonyl hydrazides were employed as coupling partners for the decarboxylative coupling reaction of propiolic acid derivatives. When the reaction was conducted using Pd(TFA) ₂ (1.0 mol%), dppp (1.0 mol%), and Cu(OAc) ₂ (2.4 equiv) in DMF at 100 °C for 0.5 hour, the desired coupled products were formed in moderate to good yields. The reaction showed good tolerance toward functional groups such as ester, ketone, cyano, nitro, chloro, and bromo groups.

Original language	English
Pages (from-to)	3197-3204
Number of pages	8
Journal	Synthesis (Germany)
Volume	50
Issue number	16
DOIs	https://doi.org/10.1055/s-0036-1591596
Publication status	Published - 2018 Jan 1

Keywords

arylalkyne
arylsulfonyl hydrazide
decarboxylative coupling
palladium
propiolic acid

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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title = "Palladium-Catalyzed Decarboxylative Coupling Reactions of Propiolic Acid Derivatives and Arylsulfonyl Hydrazide",

abstract = "Arylsulfonyl hydrazides were employed as coupling partners for the decarboxylative coupling reaction of propiolic acid derivatives. When the reaction was conducted using Pd(TFA) 2 (1.0 mol%), dppp (1.0 mol%), and Cu(OAc) 2 (2.4 equiv) in DMF at 100 °C for 0.5 hour, the desired coupled products were formed in moderate to good yields. The reaction showed good tolerance toward functional groups such as ester, ketone, cyano, nitro, chloro, and bromo groups.",

keywords = "arylalkyne, arylsulfonyl hydrazide, decarboxylative coupling, palladium, propiolic acid",

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T1 - Palladium-Catalyzed Decarboxylative Coupling Reactions of Propiolic Acid Derivatives and Arylsulfonyl Hydrazide

AU - Park, Jaerim

AU - Song, Kwang Ho

AU - Lee, Sunwoo

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Arylsulfonyl hydrazides were employed as coupling partners for the decarboxylative coupling reaction of propiolic acid derivatives. When the reaction was conducted using Pd(TFA) 2 (1.0 mol%), dppp (1.0 mol%), and Cu(OAc) 2 (2.4 equiv) in DMF at 100 °C for 0.5 hour, the desired coupled products were formed in moderate to good yields. The reaction showed good tolerance toward functional groups such as ester, ketone, cyano, nitro, chloro, and bromo groups.

AB - Arylsulfonyl hydrazides were employed as coupling partners for the decarboxylative coupling reaction of propiolic acid derivatives. When the reaction was conducted using Pd(TFA) 2 (1.0 mol%), dppp (1.0 mol%), and Cu(OAc) 2 (2.4 equiv) in DMF at 100 °C for 0.5 hour, the desired coupled products were formed in moderate to good yields. The reaction showed good tolerance toward functional groups such as ester, ketone, cyano, nitro, chloro, and bromo groups.

KW - arylalkyne

KW - arylsulfonyl hydrazide

KW - decarboxylative coupling

KW - palladium

KW - propiolic acid

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JO - Synthesis (Germany)

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Palladium-Catalyzed Decarboxylative Coupling Reactions of Propiolic Acid Derivatives and Arylsulfonyl Hydrazide

Abstract

Keywords

ASJC Scopus subject areas

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