Palladium-Catalyzed Decarboxylative Coupling Reactions of Propiolic Acid Derivatives and Arylsulfonyl Hydrazide

Jaerim Park, Kwang Ho Song, Sunwoo Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Arylsulfonyl hydrazides were employed as coupling partners for the decarboxylative coupling reaction of propiolic acid derivatives. When the reaction was conducted using Pd(TFA) 2 (1.0 mol%), dppp (1.0 mol%), and Cu(OAc) 2 (2.4 equiv) in DMF at 100 °C for 0.5 hour, the desired coupled products were formed in moderate to good yields. The reaction showed good tolerance toward functional groups such as ester, ketone, cyano, nitro, chloro, and bromo groups.

Original languageEnglish
Pages (from-to)3197-3204
Number of pages8
JournalSynthesis (Germany)
Volume50
Issue number16
DOIs
Publication statusPublished - 2018 Jan 1

Keywords

  • arylalkyne
  • arylsulfonyl hydrazide
  • decarboxylative coupling
  • palladium
  • propiolic acid

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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