Palladium-catalyzed decarboxylative trifluoroethylation of aryl alkynyl carboxylic acids

Jinil Hwang, Kyungho Park, Juseok Choe, Hongkeun Min, Kwang Ho Song, Sunwoo Lee

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

A trifluoroethylation of alkynes through a palladium-catalyzed decarboxylative coupling reaction was developed. When alkynyl carboxylic acids and ICH2CF3 were allowed to react with [Pd(? 3-allyl)Cl]2/XantPhos and Cs2CO3 in N,N-dimethylformamide (DMF) at 80 °C for 1 h, the desired products were formed in good yields. This catalytic system showed high functional group tolerance.

Original languageEnglish
Pages (from-to)3267-3271
Number of pages5
JournalJournal of Organic Chemistry
Volume79
Issue number7
DOIs
Publication statusPublished - 2014 Apr 4

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Dimethylformamide
Alkynes
Palladium
Carboxylic Acids
Functional groups
xantphos

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Palladium-catalyzed decarboxylative trifluoroethylation of aryl alkynyl carboxylic acids. / Hwang, Jinil; Park, Kyungho; Choe, Juseok; Min, Hongkeun; Song, Kwang Ho; Lee, Sunwoo.

In: Journal of Organic Chemistry, Vol. 79, No. 7, 04.04.2014, p. 3267-3271.

Research output: Contribution to journalArticle

Hwang, Jinil ; Park, Kyungho ; Choe, Juseok ; Min, Hongkeun ; Song, Kwang Ho ; Lee, Sunwoo. / Palladium-catalyzed decarboxylative trifluoroethylation of aryl alkynyl carboxylic acids. In: Journal of Organic Chemistry. 2014 ; Vol. 79, No. 7. pp. 3267-3271.
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