Palladium-Catalyzed Intermolecular Aryliodination of Internal Alkynes

Yong Ho Lee, Bill Morandi

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

A completely atom economical palladium-catalyzed addition reaction has been developed to stereoselectively access functionalized tetrasubstituted alkenyl iodides. The palladium catalyst, which bears an electron-poor bidentate ligand rarely employed in catalysis, is essential to promote the high yielding and chemoselective intermolecular reaction between equimolar amounts of an alkyne and an aryl iodide. This new carbohalogenation reaction is an attractive alternative to traditional synthetic methods, which rely on multistep synthetic sequences and protecting-group manipulations.

Original languageEnglish
Pages (from-to)6444-6448
Number of pages5
JournalAngewandte Chemie - International Edition
Volume58
Issue number19
DOIs
Publication statusPublished - 2019 May 6
Externally publishedYes

Keywords

  • alkenyl iodides
  • aryliodination
  • carbohalogenation
  • homogeneous catalysis
  • palladium

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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