Palladium-catalyzed oxidative aminocarbonylation by decarboxylative coupling: Synthesis of alkynyl amides

Jinil Hwang, Jinseop Choi, Kyungho Park, Wonyoung Kim, Kwang Ho Song, Sunwoo Lee

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Alkynyl amides were synthesized from a palladium-catalyzed coupling reaction of alkynyl carboxylic acids and amines under carbon monoxide. The reaction was conducted with palladium(II) acetate (5 mol-%) and silver(I) oxide (1.0 equiv.) in acetonitrile at 80 °C for 1 h. This method provides good to moderate product yields and good functional group tolerance towards ketone, ester, and nitrile groups.

Original languageEnglish
Pages (from-to)2235-2243
Number of pages9
JournalEuropean Journal of Organic Chemistry
Volume2015
Issue number10
DOIs
Publication statusPublished - 2015

Keywords

  • Alkynes
  • Amides
  • Carbonylation
  • Palladium
  • Synthetic methods

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry

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