Paraoxonase 1 Q192R and L55M polymorphisms and susceptibility to amyotrophic lateral sclerosis: a meta-analysis

Young Ho Lee, Jae Hoon Kim, Young Ho Seo, Sung Jae Choi, Jong Dae Ji, Gwan Gyu Song

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    6 Citations (Scopus)

    Abstract

    This study aimed to investigate whether paraoxonase 1 (PON1) Q192R and L55M polymorphisms are associated with susceptibility to amyotrophic lateral sclerosis (ALS). We conducted a meta-analysis of the associations between the PON1 Q192R and L55M polymorphisms and ALS. A total of 2,831 patients and 3,123 controls from eight studies of the PON1 Q192R polymorphism and seven studies of the PON1 L55M T polymorphism were considered for this study. Meta-analysis showed no association between ALS and the PON1 192R allele (OR = 1.052, 95 % CI = 0.923–1.207, p = 0.447), and the PON1 55M allele (OR = 1.015, 95 % CI = 0.884–1.164, p = 0.837) in all study subjects. Similarly, no association was found between ALS and the PON1 Q192R and L55M polymorphisms using recessive, dominant or homozygote contrast models. Stratification by ethnicity indicated no association between ALS and the PON1 192R allele (OR = 1.058, 95 % CI = 0.910–1.231, p = 0.464) and the PON1 55M allele (OR = 1.027, 95 % CI = 0.889–1.185, p = 0.721) in the European population. This meta-analysis showed lack of associations between PON1 Q192R and L55M polymorphisms and susceptibility to ALS in the European population.

    Original languageEnglish
    Pages (from-to)11-20
    Number of pages10
    JournalNeurological Sciences
    Volume36
    Issue number1
    DOIs
    Publication statusPublished - 2014 Jan

    Keywords

    • Amyotrophic lateral sclerosis
    • Meta-analysis
    • Paraoxonase
    • Polymorphism

    ASJC Scopus subject areas

    • Dermatology
    • Clinical Neurology
    • Psychiatry and Mental health

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