Paraoxonase 1 Q192R and L55M polymorphisms and susceptibility to amyotrophic lateral sclerosis

a meta-analysis

Young Ho Lee, Jae Hoon Kim, Young Ho Seo, Sungjae Choi, Jong Dae Ji, Gwan Gyu Song

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This study aimed to investigate whether paraoxonase 1 (PON1) Q192R and L55M polymorphisms are associated with susceptibility to amyotrophic lateral sclerosis (ALS). We conducted a meta-analysis of the associations between the PON1 Q192R and L55M polymorphisms and ALS. A total of 2,831 patients and 3,123 controls from eight studies of the PON1 Q192R polymorphism and seven studies of the PON1 L55M T polymorphism were considered for this study. Meta-analysis showed no association between ALS and the PON1 192R allele (OR = 1.052, 95 % CI = 0.923–1.207, p = 0.447), and the PON1 55M allele (OR = 1.015, 95 % CI = 0.884–1.164, p = 0.837) in all study subjects. Similarly, no association was found between ALS and the PON1 Q192R and L55M polymorphisms using recessive, dominant or homozygote contrast models. Stratification by ethnicity indicated no association between ALS and the PON1 192R allele (OR = 1.058, 95 % CI = 0.910–1.231, p = 0.464) and the PON1 55M allele (OR = 1.027, 95 % CI = 0.889–1.185, p = 0.721) in the European population. This meta-analysis showed lack of associations between PON1 Q192R and L55M polymorphisms and susceptibility to ALS in the European population.

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalNeurological Sciences
Volume36
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

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Aryldialkylphosphatase
Amyotrophic Lateral Sclerosis
Meta-Analysis
Alleles
Homozygote
Population

Keywords

  • Amyotrophic lateral sclerosis
  • Meta-analysis
  • Paraoxonase
  • Polymorphism

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Paraoxonase 1 Q192R and L55M polymorphisms and susceptibility to amyotrophic lateral sclerosis : a meta-analysis. / Lee, Young Ho; Kim, Jae Hoon; Seo, Young Ho; Choi, Sungjae; Ji, Jong Dae; Song, Gwan Gyu.

In: Neurological Sciences, Vol. 36, No. 1, 01.01.2014, p. 11-20.

Research output: Contribution to journalArticle

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abstract = "This study aimed to investigate whether paraoxonase 1 (PON1) Q192R and L55M polymorphisms are associated with susceptibility to amyotrophic lateral sclerosis (ALS). We conducted a meta-analysis of the associations between the PON1 Q192R and L55M polymorphisms and ALS. A total of 2,831 patients and 3,123 controls from eight studies of the PON1 Q192R polymorphism and seven studies of the PON1 L55M T polymorphism were considered for this study. Meta-analysis showed no association between ALS and the PON1 192R allele (OR = 1.052, 95 {\%} CI = 0.923–1.207, p = 0.447), and the PON1 55M allele (OR = 1.015, 95 {\%} CI = 0.884–1.164, p = 0.837) in all study subjects. Similarly, no association was found between ALS and the PON1 Q192R and L55M polymorphisms using recessive, dominant or homozygote contrast models. Stratification by ethnicity indicated no association between ALS and the PON1 192R allele (OR = 1.058, 95 {\%} CI = 0.910–1.231, p = 0.464) and the PON1 55M allele (OR = 1.027, 95 {\%} CI = 0.889–1.185, p = 0.721) in the European population. This meta-analysis showed lack of associations between PON1 Q192R and L55M polymorphisms and susceptibility to ALS in the European population.",
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AB - This study aimed to investigate whether paraoxonase 1 (PON1) Q192R and L55M polymorphisms are associated with susceptibility to amyotrophic lateral sclerosis (ALS). We conducted a meta-analysis of the associations between the PON1 Q192R and L55M polymorphisms and ALS. A total of 2,831 patients and 3,123 controls from eight studies of the PON1 Q192R polymorphism and seven studies of the PON1 L55M T polymorphism were considered for this study. Meta-analysis showed no association between ALS and the PON1 192R allele (OR = 1.052, 95 % CI = 0.923–1.207, p = 0.447), and the PON1 55M allele (OR = 1.015, 95 % CI = 0.884–1.164, p = 0.837) in all study subjects. Similarly, no association was found between ALS and the PON1 Q192R and L55M polymorphisms using recessive, dominant or homozygote contrast models. Stratification by ethnicity indicated no association between ALS and the PON1 192R allele (OR = 1.058, 95 % CI = 0.910–1.231, p = 0.464) and the PON1 55M allele (OR = 1.027, 95 % CI = 0.889–1.185, p = 0.721) in the European population. This meta-analysis showed lack of associations between PON1 Q192R and L55M polymorphisms and susceptibility to ALS in the European population.

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