Abstract
Objective Persistent elevation of urinary albumin excretion (UAE), even within normal range, is an independent predictor for cardiovascular disease. Accumulating research suggests that low levels of vitamin D and high levels of parathyroid hormone (PTH) also increase cardiovascular disease risk. This study is intended to investigate the relationship between PTH, vitamin D levels and UAE. Methods We examined 2897 adults aged 50 and above, participating in the second year of the fifth Korea National Health and Nutrition Examination Survey (KNHANES V-2). Anthropometric and laboratory measurements were performed. Elevated UAE was defined as spot urinary albumin creatinine ratio equal or above 10. Results The proportion of elevated UAE (21·8%, 23·2%, 23·2%, 31·8%; P for trend = 0·002) rose with increasing quartiles of PTH. The odds ratio for elevated UAE in the highest quartile of PTH was 72% higher than the lowest quartile group. There was no relationship between vitamin D and elevated UAE. Conclusions Elevated PTH levels are associated with elevated UAE in Korean adults aged 50 and above. Additional studies are needed to clarify this relationship.
| Original language | English |
|---|---|
| Pages (from-to) | 34-40 |
| Number of pages | 7 |
| Journal | Clinical Endocrinology |
| Volume | 80 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
Cite this
Parathyroid hormone, vitamin D levels and urine albumin excretion in older persons : The 2011 Korea National Health and Nutrition Examination Survey (KNHANES). / Kim, Hyun Woo; Park, Hyunkyoung; Cho, Kyung-Hwan; Han, Kyungdo; Ko, Byung Joon.
In: Clinical Endocrinology, Vol. 80, No. 1, 01.01.2014, p. 34-40.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Parathyroid hormone, vitamin D levels and urine albumin excretion in older persons
T2 - The 2011 Korea National Health and Nutrition Examination Survey (KNHANES)
AU - Kim, Hyun Woo
AU - Park, Hyunkyoung
AU - Cho, Kyung-Hwan
AU - Han, Kyungdo
AU - Ko, Byung Joon
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Objective Persistent elevation of urinary albumin excretion (UAE), even within normal range, is an independent predictor for cardiovascular disease. Accumulating research suggests that low levels of vitamin D and high levels of parathyroid hormone (PTH) also increase cardiovascular disease risk. This study is intended to investigate the relationship between PTH, vitamin D levels and UAE. Methods We examined 2897 adults aged 50 and above, participating in the second year of the fifth Korea National Health and Nutrition Examination Survey (KNHANES V-2). Anthropometric and laboratory measurements were performed. Elevated UAE was defined as spot urinary albumin creatinine ratio equal or above 10. Results The proportion of elevated UAE (21·8%, 23·2%, 23·2%, 31·8%; P for trend = 0·002) rose with increasing quartiles of PTH. The odds ratio for elevated UAE in the highest quartile of PTH was 72% higher than the lowest quartile group. There was no relationship between vitamin D and elevated UAE. Conclusions Elevated PTH levels are associated with elevated UAE in Korean adults aged 50 and above. Additional studies are needed to clarify this relationship.
AB - Objective Persistent elevation of urinary albumin excretion (UAE), even within normal range, is an independent predictor for cardiovascular disease. Accumulating research suggests that low levels of vitamin D and high levels of parathyroid hormone (PTH) also increase cardiovascular disease risk. This study is intended to investigate the relationship between PTH, vitamin D levels and UAE. Methods We examined 2897 adults aged 50 and above, participating in the second year of the fifth Korea National Health and Nutrition Examination Survey (KNHANES V-2). Anthropometric and laboratory measurements were performed. Elevated UAE was defined as spot urinary albumin creatinine ratio equal or above 10. Results The proportion of elevated UAE (21·8%, 23·2%, 23·2%, 31·8%; P for trend = 0·002) rose with increasing quartiles of PTH. The odds ratio for elevated UAE in the highest quartile of PTH was 72% higher than the lowest quartile group. There was no relationship between vitamin D and elevated UAE. Conclusions Elevated PTH levels are associated with elevated UAE in Korean adults aged 50 and above. Additional studies are needed to clarify this relationship.
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U2 - 10.1111/cen.12246
DO - 10.1111/cen.12246
M3 - Article
C2 - 23679090
AN - SCOPUS:84889609291
VL - 80
SP - 34
EP - 40
JO - Clinical Endocrinology
JF - Clinical Endocrinology
SN - 0300-0664
IS - 1
ER -