Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors

Ja Hyun Baik; Roberto Picetti; Adolfo Saiardi; Graziella Thiriet; Andrée Dierich; Antoine Depaulis; Marianne Le Meur; Emiliana Borrelli

doi:10.1038/377424a0

Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors

Ja Hyun Baik, Roberto Picetti, Adolfo Saiardi, Graziella Thiriet, Andrée Dierich, Antoine Depaulis, Marianne Le Meur, Emiliana Borrelli

Research output: Contribution to journal › Letter › peer-review

563 Citations (Scopus)

Abstract

DOPAMINERGIC neuronal pathways arise from mesencephalic nuclei and project axons to the striatum, cortex, limbic system and hypothalamus^1,2. Through these pathways dopamine affects many physiological functions, such as the control of coordinated movement and hormone secretion³. Here we have studied the physiological involvement of the dopamine D2 receptors in dopaminergic transmission, using homologous recombination to generate D2-receptor-deficient mice. Absence of D2 receptors leads to animals that are akinetic and bradykinetic in behavioural tests, and which show significantly reduced spontaneous movements. This pheno-type presents analogies with symptoms characteristic of Parkin-son's disease^4,5. Our study shows that D2 receptors have a key role in the dopaminergic control of nervous function. These mice have therapeutic potential as a model for investigating and correcting dysfunctions of the dopaminergic system.

Original language	English
Pages (from-to)	424-428
Number of pages	5
Journal	Nature
Volume	377
Issue number	6548
DOIs	https://doi.org/10.1038/377424a0
Publication status	Published - 1995 Oct 5
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1038/377424a0

Fingerprint Dive into the research topics of 'Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors'. Together they form a unique fingerprint.

Cite this

@article{4ebb10bc9b764d3590a594055c0d97c6,

title = "Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors",

abstract = "DOPAMINERGIC neuronal pathways arise from mesencephalic nuclei and project axons to the striatum, cortex, limbic system and hypothalamus1,2. Through these pathways dopamine affects many physiological functions, such as the control of coordinated movement and hormone secretion3. Here we have studied the physiological involvement of the dopamine D2 receptors in dopaminergic transmission, using homologous recombination to generate D2-receptor-deficient mice. Absence of D2 receptors leads to animals that are akinetic and bradykinetic in behavioural tests, and which show significantly reduced spontaneous movements. This pheno-type presents analogies with symptoms characteristic of Parkin-son's disease4,5. Our study shows that D2 receptors have a key role in the dopaminergic control of nervous function. These mice have therapeutic potential as a model for investigating and correcting dysfunctions of the dopaminergic system.",

author = "Baik, {Ja Hyun} and Roberto Picetti and Adolfo Saiardi and Graziella Thiriet and Andr{\'e}e Dierich and Antoine Depaulis and {Le Meur}, Marianne and Emiliana Borrelli",

year = "1995",

month = oct,

day = "5",

doi = "10.1038/377424a0",

language = "English",

volume = "377",

pages = "424--428",

journal = "Nature Cell Biology",

issn = "1465-7392",

publisher = "Nature Publishing Group",

number = "6548",

}

TY - JOUR

T1 - Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors

AU - Baik, Ja Hyun

AU - Picetti, Roberto

AU - Saiardi, Adolfo

AU - Thiriet, Graziella

AU - Dierich, Andrée

AU - Depaulis, Antoine

AU - Le Meur, Marianne

AU - Borrelli, Emiliana

PY - 1995/10/5

Y1 - 1995/10/5

N2 - DOPAMINERGIC neuronal pathways arise from mesencephalic nuclei and project axons to the striatum, cortex, limbic system and hypothalamus1,2. Through these pathways dopamine affects many physiological functions, such as the control of coordinated movement and hormone secretion3. Here we have studied the physiological involvement of the dopamine D2 receptors in dopaminergic transmission, using homologous recombination to generate D2-receptor-deficient mice. Absence of D2 receptors leads to animals that are akinetic and bradykinetic in behavioural tests, and which show significantly reduced spontaneous movements. This pheno-type presents analogies with symptoms characteristic of Parkin-son's disease4,5. Our study shows that D2 receptors have a key role in the dopaminergic control of nervous function. These mice have therapeutic potential as a model for investigating and correcting dysfunctions of the dopaminergic system.

AB - DOPAMINERGIC neuronal pathways arise from mesencephalic nuclei and project axons to the striatum, cortex, limbic system and hypothalamus1,2. Through these pathways dopamine affects many physiological functions, such as the control of coordinated movement and hormone secretion3. Here we have studied the physiological involvement of the dopamine D2 receptors in dopaminergic transmission, using homologous recombination to generate D2-receptor-deficient mice. Absence of D2 receptors leads to animals that are akinetic and bradykinetic in behavioural tests, and which show significantly reduced spontaneous movements. This pheno-type presents analogies with symptoms characteristic of Parkin-son's disease4,5. Our study shows that D2 receptors have a key role in the dopaminergic control of nervous function. These mice have therapeutic potential as a model for investigating and correcting dysfunctions of the dopaminergic system.

UR - http://www.scopus.com/inward/record.url?scp=0029165456&partnerID=8YFLogxK

U2 - 10.1038/377424a0

DO - 10.1038/377424a0

M3 - Letter

C2 - 7566118

AN - SCOPUS:0029165456

VL - 377

SP - 424

EP - 428

JO - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

IS - 6548

ER -

Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this