Particle numbers of lipoprotein subclasses and arterial stiffness among middle-aged men from the ERA JUMP study

A. Vishnu, Jina Choo, K. H. Masaki, R. H. Mackey, E. Barinas-Mitchell, Chol Shin, B. J. Willcox, A. El-Saed, T. B. Seto, A. Fujiyoshi, K. Miura, S. Lee, K. Sutton-Tyrrell, L. H. Kuller, H. Ueshima, A. Sekikawa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We examined the association between serum lipoprotein subclasses and the three measures of arterial stiffness, that is, (i) carotid-femoral pulse wave velocity (cfPWV), which is a gold standard measure of central arterial stiffness, (ii) brachial-ankle PWV (baPWV), which is emerging as a combined measure of central and peripheral arterial stiffness and (iii) femoral-ankle PWV (faPWV), which is a measure of peripheral arterial stiffness. Among a population-based sample of 701 apparently healthy Caucasian, Japanese American and Korean men aged 40-49 years, concentrations of lipoprotein particles were assessed by nuclear magnetic resonance (NMR) spectroscopy, and the PWV was assessed with an automated waveform analyzer (VP2000, Omron, Japan). Multiple linear regressions were performed to analyse the association between each NMR lipoprotein subclasses and PWV measures, after adjusting for cardiovascular risk factors and other confounders. A cutoff of P<0.01 was used for determining significance. All PWV measures had significant correlations with total and small low-density lipoprotein particle number (LDL-P) (all P<0.0001) but not LDL cholesterol (LDL-C) (all P>0.1), independent of race and age. In multivariate regression analysis, no NMR lipoprotein subclass was significantly associated with cfPWV (all P>0.01). However, most NMR lipoprotein subclasses had significant associations with both baPWV and faPWV (P<0.01). In this study of healthy middle-aged men, as compared with cfPWV, both baPWV and faPWV had stronger associations with particle numbers of lipoprotein subclasses. Our results may suggest that both baPWV and faPWV are related to arterial stiffness and atherosclerosis, whereas cfPWV may represent arterial stiffness alone.

Original languageEnglish
Pages (from-to)111-117
Number of pages7
JournalJournal of Human Hypertension
Volume28
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Vascular Stiffness
Thigh
Ankle
Lipoproteins
Pulse Wave Analysis
Arm
Magnetic Resonance Spectroscopy
Carotid Artery Diseases
Asian Americans
Linear Models
Japan
Multivariate Analysis
Regression Analysis
Serum

Keywords

  • Atherosclerosis
  • Lipoprotein fractions
  • Lipoproteins
  • Pulse wave velocity

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Particle numbers of lipoprotein subclasses and arterial stiffness among middle-aged men from the ERA JUMP study. / Vishnu, A.; Choo, Jina; Masaki, K. H.; Mackey, R. H.; Barinas-Mitchell, E.; Shin, Chol; Willcox, B. J.; El-Saed, A.; Seto, T. B.; Fujiyoshi, A.; Miura, K.; Lee, S.; Sutton-Tyrrell, K.; Kuller, L. H.; Ueshima, H.; Sekikawa, A.

In: Journal of Human Hypertension, Vol. 28, No. 2, 01.01.2014, p. 111-117.

Research output: Contribution to journalArticle

Vishnu, A, Choo, J, Masaki, KH, Mackey, RH, Barinas-Mitchell, E, Shin, C, Willcox, BJ, El-Saed, A, Seto, TB, Fujiyoshi, A, Miura, K, Lee, S, Sutton-Tyrrell, K, Kuller, LH, Ueshima, H & Sekikawa, A 2014, 'Particle numbers of lipoprotein subclasses and arterial stiffness among middle-aged men from the ERA JUMP study', Journal of Human Hypertension, vol. 28, no. 2, pp. 111-117. https://doi.org/10.1038/jhh.2013.60
Vishnu, A. ; Choo, Jina ; Masaki, K. H. ; Mackey, R. H. ; Barinas-Mitchell, E. ; Shin, Chol ; Willcox, B. J. ; El-Saed, A. ; Seto, T. B. ; Fujiyoshi, A. ; Miura, K. ; Lee, S. ; Sutton-Tyrrell, K. ; Kuller, L. H. ; Ueshima, H. ; Sekikawa, A. / Particle numbers of lipoprotein subclasses and arterial stiffness among middle-aged men from the ERA JUMP study. In: Journal of Human Hypertension. 2014 ; Vol. 28, No. 2. pp. 111-117.
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