Particulate matter (PM)2.5 affects keratinocytes via endoplasmic reticulum (ER) stress-mediated suppression of apoptosis

J. H. Kim, J. W. Son, J. Kim, M. G. Kim, S. H. Jeong, T. J. Park, S. W. Son, H. J. Ryu

Research output: Contribution to journalArticle

Abstract

Background: Particulate matter (PM)2.5 is a concern for public health nowadays. Although few studies have reported the skin diseases associated with PM2.5, its effects on keratinocytes have yet to be elucidated. Objective: The goal of this experiment was to analyze and identify the changes of gene expression in PM2.5-treated keratinocytes using RNA-sequencing (RNA-Seq) data. Results: PM2.5-treated keratinocytes exhibited changes in cell cycle-related genes as well as genes involved in DNA replication, endoplasmic reticulum (ER) stress, intrinsic apoptosis, and immune response. A total of 669 genes showed changes in gene expression in PM2.5-treated keratinocytes, including 304 upregulated and 365 downregulated genes. Conclusion: Unlike other studies investigating skin disorders associated with PM2.5, our study found the mechanism of apoptosis suppression in keratinocytes. The findings may provide a novel insight into the management of chronic skin diseases in relation to PM2.5.

Original languageEnglish
JournalMolecular and Cellular Toxicology
DOIs
Publication statusAccepted/In press - 2020 Jan 1

Keywords

  • Apoptosis
  • Cell proliferation
  • Endoplasmic reticulum (ER) stress
  • Particulate matter (PM)
  • Psoriasis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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