Paternal exposure to irbesartan coadministered with multiple antihypertensive and antidiabetic drugs

A case report of a baby born healthy

Soon Cheol Hong, Jung Yeol Han, June Seek Choi, Hyun Kyong Ahn, E. Yadira Velázquez-Armenta, Alejandro A. Nava-Ocampo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To report the fetal outcome of a baby with paternal exposure to irbesartan and other antihypertensive and antidiabetic drugs. Case: The baby was conceived by in vitro fertilization with an egg obtained from a woman with untreated diabetes and hypertension and the sperm from a male with type-2 diabetes and hypertension. At the time of sperm donation, he was taking irbesartan 150 mg d-1 in addition to amlodipine, aspirin, carvedilol, glibenclamide, hydrochlorothiazide, metformin, ramipril, and triazolam. At 38 weeks gestation, a 3,090 g female baby was delivered by cesarean section due to placenta previa. At 40 months postnatal age, the baby was 18 kg with normal growth and development. Conclusion: This case suggests that paternal exposure to irbesartan as part of a combination therapy with other antihypertensive drugs and antidiabetics, does not alter sperm cells or increase the risk for fetal malformations.

Original languageEnglish
Pages (from-to)24-26
Number of pages3
JournalJournal of Clinical Pharmacology and Pharmacoepidemiology
Volume1
Issue number1
Publication statusPublished - 2010 Jun 15

Fingerprint

irbesartan
Paternal Exposure
Hypoglycemic Agents
Antihypertensive Agents
Spermatozoa
Medical problems
Triazolam
Ramipril
Hypertension
Placenta Previa
Amlodipine
Hydrochlorothiazide
Glyburide
Metformin
Fertilization in Vitro
Growth and Development
Cesarean Section
Type 2 Diabetes Mellitus
Aspirin
Ovum

Keywords

  • Angiotensin II type 1 receptor blockers
  • Antihypertensive agents
  • Paternal exposure
  • Sartans

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Epidemiology
  • Pharmacology

Cite this

Paternal exposure to irbesartan coadministered with multiple antihypertensive and antidiabetic drugs : A case report of a baby born healthy. / Hong, Soon Cheol; Han, Jung Yeol; Choi, June Seek; Ahn, Hyun Kyong; Velázquez-Armenta, E. Yadira; Nava-Ocampo, Alejandro A.

In: Journal of Clinical Pharmacology and Pharmacoepidemiology, Vol. 1, No. 1, 15.06.2010, p. 24-26.

Research output: Contribution to journalArticle

Hong, Soon Cheol ; Han, Jung Yeol ; Choi, June Seek ; Ahn, Hyun Kyong ; Velázquez-Armenta, E. Yadira ; Nava-Ocampo, Alejandro A. / Paternal exposure to irbesartan coadministered with multiple antihypertensive and antidiabetic drugs : A case report of a baby born healthy. In: Journal of Clinical Pharmacology and Pharmacoepidemiology. 2010 ; Vol. 1, No. 1. pp. 24-26.
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