TY - JOUR
T1 - Paternal exposure to irbesartan coadministered with multiple antihypertensive and antidiabetic drugs
T2 - A case report of a baby born healthy
AU - Hong, Soon Cheol
AU - Han, Jung Yeol
AU - Choi, June Seek
AU - Ahn, Hyun Kyong
AU - Velázquez-Armenta, E. Yadira
AU - Nava-Ocampo, Alejandro A.
PY - 2010
Y1 - 2010
N2 - Objective: To report the fetal outcome of a baby with paternal exposure to irbesartan and other antihypertensive and antidiabetic drugs. Case: The baby was conceived by in vitro fertilization with an egg obtained from a woman with untreated diabetes and hypertension and the sperm from a male with type-2 diabetes and hypertension. At the time of sperm donation, he was taking irbesartan 150 mg d-1 in addition to amlodipine, aspirin, carvedilol, glibenclamide, hydrochlorothiazide, metformin, ramipril, and triazolam. At 38 weeks gestation, a 3,090 g female baby was delivered by cesarean section due to placenta previa. At 40 months postnatal age, the baby was 18 kg with normal growth and development. Conclusion: This case suggests that paternal exposure to irbesartan as part of a combination therapy with other antihypertensive drugs and antidiabetics, does not alter sperm cells or increase the risk for fetal malformations.
AB - Objective: To report the fetal outcome of a baby with paternal exposure to irbesartan and other antihypertensive and antidiabetic drugs. Case: The baby was conceived by in vitro fertilization with an egg obtained from a woman with untreated diabetes and hypertension and the sperm from a male with type-2 diabetes and hypertension. At the time of sperm donation, he was taking irbesartan 150 mg d-1 in addition to amlodipine, aspirin, carvedilol, glibenclamide, hydrochlorothiazide, metformin, ramipril, and triazolam. At 38 weeks gestation, a 3,090 g female baby was delivered by cesarean section due to placenta previa. At 40 months postnatal age, the baby was 18 kg with normal growth and development. Conclusion: This case suggests that paternal exposure to irbesartan as part of a combination therapy with other antihypertensive drugs and antidiabetics, does not alter sperm cells or increase the risk for fetal malformations.
KW - Angiotensin II type 1 receptor blockers
KW - Antihypertensive agents
KW - Paternal exposure
KW - Sartans
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M3 - Article
AN - SCOPUS:77953332208
VL - 1
SP - 24
EP - 26
JO - Journal of Clinical Pharmacology and Pharmacoepidemiology
JF - Journal of Clinical Pharmacology and Pharmacoepidemiology
SN - 1916-694X
IS - 1
ER -