Pathogenesis of and immunity to a new influenza A (H5N1) virus isolated from duck meat

X. H. Lu, D. Cho, H. Hall, T. Rowe, I. P. Mo, H. W. Sung, Woo Joo Kim, C. Kang, N. Cox, A. Klimov, J. M. Katz

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The outbreak of avian influenza H5N1 in Hong Kong in 1997 raised concerns about the potential for the H5 subtype to cause a human pandemic. In 2001 a new H5N1 virus, A/Duck Meat/Anyang/AVL-1/2001 (A/Dkmt), was isolated from imported duck meat in Korea. The pathogenesis of this virus was investigated in mice. A/Dkmt virus had low infectivity but was lethal for mice at high doses, and at lethal doses, the virus replicated in the brains of infected mice. A/Dkmt virus cross-reacted poorly with ferret antisera raised against human H5N1 viruses, but prior infection with A/Dkmt virus protected mice from death after secondary infection with human H5N1 virus.

Original languageEnglish
Pages (from-to)1135-1140
Number of pages6
JournalAvian Diseases
Volume47
Issue numberSPEC. ISS.
Publication statusPublished - 2003 Oct 1
Externally publishedYes

Fingerprint

duck meat
H5N1 Subtype Influenza A Virus
Ducks
Influenza A virus
influenza
Meat
Immunity
pathogenesis
immunity
Viruses
viruses
mice
Ferrets
Influenza in Birds
ferrets
lethal dose
avian influenza
Hong Kong
Pandemics
pandemic

Keywords

  • Antigenicity
  • Avian influenza virus
  • Cross-protection
  • Pathogenesis

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology
  • Immunology and Microbiology(all)

Cite this

Lu, X. H., Cho, D., Hall, H., Rowe, T., Mo, I. P., Sung, H. W., ... Katz, J. M. (2003). Pathogenesis of and immunity to a new influenza A (H5N1) virus isolated from duck meat. Avian Diseases, 47(SPEC. ISS.), 1135-1140.

Pathogenesis of and immunity to a new influenza A (H5N1) virus isolated from duck meat. / Lu, X. H.; Cho, D.; Hall, H.; Rowe, T.; Mo, I. P.; Sung, H. W.; Kim, Woo Joo; Kang, C.; Cox, N.; Klimov, A.; Katz, J. M.

In: Avian Diseases, Vol. 47, No. SPEC. ISS., 01.10.2003, p. 1135-1140.

Research output: Contribution to journalArticle

Lu, XH, Cho, D, Hall, H, Rowe, T, Mo, IP, Sung, HW, Kim, WJ, Kang, C, Cox, N, Klimov, A & Katz, JM 2003, 'Pathogenesis of and immunity to a new influenza A (H5N1) virus isolated from duck meat', Avian Diseases, vol. 47, no. SPEC. ISS., pp. 1135-1140.
Lu XH, Cho D, Hall H, Rowe T, Mo IP, Sung HW et al. Pathogenesis of and immunity to a new influenza A (H5N1) virus isolated from duck meat. Avian Diseases. 2003 Oct 1;47(SPEC. ISS.):1135-1140.
Lu, X. H. ; Cho, D. ; Hall, H. ; Rowe, T. ; Mo, I. P. ; Sung, H. W. ; Kim, Woo Joo ; Kang, C. ; Cox, N. ; Klimov, A. ; Katz, J. M. / Pathogenesis of and immunity to a new influenza A (H5N1) virus isolated from duck meat. In: Avian Diseases. 2003 ; Vol. 47, No. SPEC. ISS. pp. 1135-1140.
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