Pathogenesis of and immunity to a new influenza A (H5N1) virus isolated from duck meat

X. H. Lu, D. Cho, H. Hall, T. Rowe, I. P. Mo, H. W. Sung, W. J. Kim, C. Kang, N. Cox, A. Klimov, J. M. Katz

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5 Citations (Scopus)

Abstract

The outbreak of avian influenza H5N1 in Hong Kong in 1997 raised concerns about the potential for the H5 subtype to cause a human pandemic. In 2001 a new H5N1 virus, A/Duck Meat/Anyang/AVL-1/2001 (A/Dkmt), was isolated from imported duck meat in Korea. The pathogenesis of this virus was investigated in mice. A/Dkmt virus had low infectivity but was lethal for mice at high doses, and at lethal doses, the virus replicated in the brains of infected mice. A/Dkmt virus cross-reacted poorly with ferret antisera raised against human H5N1 viruses, but prior infection with A/Dkmt virus protected mice from death after secondary infection with human H5N1 virus.

Original languageEnglish
Pages (from-to)1135-1140
Number of pages6
JournalAvian Diseases
Volume47
Issue numberSPEC. ISS.
DOIs
Publication statusPublished - 2003

Keywords

  • Antigenicity
  • Avian influenza virus
  • Cross-protection
  • Pathogenesis

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology
  • Immunology and Microbiology(all)

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    Lu, X. H., Cho, D., Hall, H., Rowe, T., Mo, I. P., Sung, H. W., Kim, W. J., Kang, C., Cox, N., Klimov, A., & Katz, J. M. (2003). Pathogenesis of and immunity to a new influenza A (H5N1) virus isolated from duck meat. Avian Diseases, 47(SPEC. ISS.), 1135-1140. https://doi.org/10.1637/0005-2086-47.s3.1135