Pathogenic role of serine protease HtrA2/Omi in neurodegenerative diseases

Hui Gwan Goo, Hyangshuk Rhim, Seong Man Kang

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

High-temperature-requirement A2 (HtrA2)/Omi/PARK13 is a serine protease with extensive homology to the Escherichia coli HtrAs that are required for bacterial survival at high temperatures. The HtrA2 protein is a key modulator of mitochondrial molecular quality control but under stressful conditions it is released into the cytosol, where it promotes cell death by various pathways, including caspase-dependent pathway and ER stress-mediated apoptosis. Recently, the HtrA2 protein has received great attention for its potential role in neurodegeneration. Here, we review the current knowledge and pathophysiological functions of the HtrA2 protein in neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease.

Original languageEnglish
Pages (from-to)746-757
Number of pages12
JournalCurrent Protein and Peptide Science
Volume18
Issue number7
DOIs
Publication statusPublished - 2017

Fingerprint

Neurodegenerative diseases
Serine Proteases
varespladib methyl
Neurodegenerative Diseases
Temperature
Proteins
Cell death
Caspases
Quality Control
Cytosol
Escherichia coli
Modulators
Quality control
Parkinson Disease
Alzheimer Disease
Cell Death
Apoptosis

Keywords

  • Alzheimer’s disease
  • Apoptosis
  • HtrA2
  • HtrA2 interacting proteins
  • Mitochondria
  • Parkinson’s disease
  • Protein quality control

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Pathogenic role of serine protease HtrA2/Omi in neurodegenerative diseases. / Goo, Hui Gwan; Rhim, Hyangshuk; Kang, Seong Man.

In: Current Protein and Peptide Science, Vol. 18, No. 7, 2017, p. 746-757.

Research output: Contribution to journalReview article

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