Pathogenic role of serine protease HtrA2/Omi in neurodegenerative diseases

Hui Gwan Goo, Hyangshuk Rhim, Seongman Kang

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)


High-temperature-requirement A2 (HtrA2)/Omi/PARK13 is a serine protease with extensive homology to the Escherichia coli HtrAs that are required for bacterial survival at high temperatures. The HtrA2 protein is a key modulator of mitochondrial molecular quality control but under stressful conditions it is released into the cytosol, where it promotes cell death by various pathways, including caspase-dependent pathway and ER stress-mediated apoptosis. Recently, the HtrA2 protein has received great attention for its potential role in neurodegeneration. Here, we review the current knowledge and pathophysiological functions of the HtrA2 protein in neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease.

Original languageEnglish
Pages (from-to)746-757
Number of pages12
JournalCurrent Protein and Peptide Science
Issue number1
Publication statusPublished - 2017


  • Alzheimer’s disease
  • Apoptosis
  • HtrA2
  • HtrA2 interacting proteins
  • Mitochondria
  • Parkinson’s disease
  • Protein quality Control

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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