Korean Source 20Korean Source Langerin (CD207)Korean Source

Translated title of the contribution: Pathological characteristics of 20 cases of langerhans cell histiocytosis and specificity of immunohistochemical stain of langerin (CD207)

Youngjoon Ryu, Hyunjoo Lee, Sangho Lee, Hoiseon Jeong, Bong Kyung Shin, Aeree Kim, Han Kyeom Kim, Insun Kim

Research output: Contribution to journalArticle

Abstract

Background: Langerhans cell histiocytosis (LCH) is a well-known neoplastic disorder of Langerhans cells which has characteristic findings, however, LCH has not been adequately studied in Korea. Methods: We analyzed the clinicopathologic features of 20 patients with LCH who were diagnosed between 1997 and 2006 at the Korea University Guro and Anam Hospitals. Results: The M:F ratio was 3:1 and the age ranged from 2-60 years (mean, 23.8 years [4 in 1st decade, 6 in 2nd decade, 2 in 3rd decade, 5 in 4th decade and 3≥40 years of age). The cases were classified as unifocal unisystemic in 13 patients, multifocal unisystemic in 4 patients, and multifocal multisystemic in 3 patients. The bone was the most commonly involved organ (14), followed by lymph node (5), lung (2), skin (2) and ureter (1). The Langerhans cells were immunohistochemically stained with Langerin, CD1a, S-100 protein, and CD68. Langerin and CD1a were specific for Langerhans cells. Conclusions: The distribution of the involved organs in patients with LCH was similar to the distribution in Western countries, but lymph node involvement was more frequent, whereas lung involvement was less common. Langerin is considered to be a specific marker for Langerhans cells.

Original languageKorean
Pages (from-to)113-119
Number of pages7
JournalKorean Journal of Pathology
Volume43
Issue number2
DOIs
Publication statusPublished - 2009 Apr 1

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Langerhans Cell Histiocytosis
Langerhans Cells
Coloring Agents
Korea
Lymph Nodes
Lung
S100 Proteins
Ureter
Bone and Bones
Skin

Keywords

  • Langerhans-cell histiocytosis
  • Langerin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Korean Source 20Korean Source Langerin (CD207)Korean Source. / Ryu, Youngjoon; Lee, Hyunjoo; Lee, Sangho; Jeong, Hoiseon; Shin, Bong Kyung; Kim, Aeree; Kim, Han Kyeom; Kim, Insun.

In: Korean Journal of Pathology, Vol. 43, No. 2, 01.04.2009, p. 113-119.

Research output: Contribution to journalArticle

Ryu, Youngjoon ; Lee, Hyunjoo ; Lee, Sangho ; Jeong, Hoiseon ; Shin, Bong Kyung ; Kim, Aeree ; Kim, Han Kyeom ; Kim, Insun. / Korean Source 20Korean Source Langerin (CD207)Korean Source. In: Korean Journal of Pathology. 2009 ; Vol. 43, No. 2. pp. 113-119.
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