Pathology of cholangiocarcinoma

Trishe Y.M. Leong, Pongsak Wannakrairot, Eung Seok Lee, Anthony S.Y. Leong

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Cholangiocarcinoma, which is endemic in certain geographic regions, shows a strong association with liver fluke infection and hepatolithiasis, with recurrent inflammation and the high consumption of nitrates, nitrites, dimethylnitrosamines and N-nitropyrolidines as probable mutagenic cofactors. K-ras, p53 and bcl-2 have been implicated in cholangiocarcinogenesis and several immunohistological markers have been studied, although none is a reliable predictor of outcome. Three macroscopic types of cholangiocarcinoma have been characterized and implicated to be of prognostic relevance, but their behaviour might be a function of their anatomical location rather than a biological characteristic. Periductal-infiltrating tumours present at an advanced stage with infiltration of the portal pedicle. They arise closer to the hepatic hilum than mass-forming tumours, which tend to be peripherally located and show portal invasion and intrahepatic recurrence. The intraductal tumour shows the best prognosis, and long-term survival has been reported. Poor prognostic factors include large tumour size, multifocality, lymphovascular, perineural and serosal invasion, lymph node metastases and involvement of resection margins. Survival following surgical resection, the mainstay of treatment, is generally very poor.

Original languageEnglish
Pages (from-to)54-64
Number of pages11
JournalCurrent Diagnostic Pathology
Volume13
Issue number1
DOIs
Publication statusPublished - 2007 Feb 1

Fingerprint

Cholangiocarcinoma
Pathology
Neoplasms
Dimethylnitrosamine
Fasciola hepatica
Nitrites
Nitrates
Lymph Nodes
Neoplasm Metastasis
Inflammation
Recurrence
Liver
Infection

Keywords

  • Cholangiocarcinoma
  • Histopathology
  • Immunohistochemistry
  • Intraductal papillary carcinoma
  • Prognosis
  • Prognostic factors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Leong, T. Y. M., Wannakrairot, P., Lee, E. S., & Leong, A. S. Y. (2007). Pathology of cholangiocarcinoma. Current Diagnostic Pathology, 13(1), 54-64. https://doi.org/10.1016/j.cdip.2006.07.006

Pathology of cholangiocarcinoma. / Leong, Trishe Y.M.; Wannakrairot, Pongsak; Lee, Eung Seok; Leong, Anthony S.Y.

In: Current Diagnostic Pathology, Vol. 13, No. 1, 01.02.2007, p. 54-64.

Research output: Contribution to journalArticle

Leong, TYM, Wannakrairot, P, Lee, ES & Leong, ASY 2007, 'Pathology of cholangiocarcinoma', Current Diagnostic Pathology, vol. 13, no. 1, pp. 54-64. https://doi.org/10.1016/j.cdip.2006.07.006
Leong, Trishe Y.M. ; Wannakrairot, Pongsak ; Lee, Eung Seok ; Leong, Anthony S.Y. / Pathology of cholangiocarcinoma. In: Current Diagnostic Pathology. 2007 ; Vol. 13, No. 1. pp. 54-64.
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