Patterning protein molecules on poly(ethylene glycol) coated Si(1 1 1)

Yongseok Jun, Taewoon Cha, Athena Guo, X. Y. Zhu

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


We demonstrate spatially localized immobilization of protein molecules on high-density poly(ethylene glycol) (PEG) coated Si(111). Patterns of HO- and CH3O-terminated PEG regions are formed on silicon surfaces based on soft lithography techniques and an efficient reaction between alcohol functional groups and chlorine-terminated silicon. Activation of the HO-terminated PEG brush is achieved via either partial oxidation to form aldehyde groups or via attachment of efficient leaving groups. Protein molecules are covalently immobilized to these activated regions on the PEG/Si surface.

Original languageEnglish
Pages (from-to)3503-3509
Number of pages7
Issue number17
Publication statusPublished - 2004 Aug
Externally publishedYes


  • Polyethylene oxide
  • Protein adsorption
  • Surface grafting
  • Surface modification

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials


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