Patterning protein molecules on poly(ethylene glycol) coated Si(1 1 1)

Yongseok Jun, Taewoon Cha, Athena Guo, X. Y. Zhu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We demonstrate spatially localized immobilization of protein molecules on high-density poly(ethylene glycol) (PEG) coated Si(111). Patterns of HO- and CH3O-terminated PEG regions are formed on silicon surfaces based on soft lithography techniques and an efficient reaction between alcohol functional groups and chlorine-terminated silicon. Activation of the HO-terminated PEG brush is achieved via either partial oxidation to form aldehyde groups or via attachment of efficient leaving groups. Protein molecules are covalently immobilized to these activated regions on the PEG/Si surface.

Original languageEnglish
Pages (from-to)3503-3509
Number of pages7
JournalBiomaterials
Volume25
Issue number17
DOIs
Publication statusPublished - 2004 Aug 1
Externally publishedYes

Fingerprint

Ethylene Glycol
Silicon
Polyethylene glycols
Proteins
Molecules
Chlorine
Aldehydes
Immobilization
Alcohols
Brushes
Lithography
Functional groups
Chemical activation
Oxidation

Keywords

  • Polyethylene oxide
  • Protein adsorption
  • Surface grafting
  • Surface modification

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Patterning protein molecules on poly(ethylene glycol) coated Si(1 1 1). / Jun, Yongseok; Cha, Taewoon; Guo, Athena; Zhu, X. Y.

In: Biomaterials, Vol. 25, No. 17, 01.08.2004, p. 3503-3509.

Research output: Contribution to journalArticle

Jun, Yongseok ; Cha, Taewoon ; Guo, Athena ; Zhu, X. Y. / Patterning protein molecules on poly(ethylene glycol) coated Si(1 1 1). In: Biomaterials. 2004 ; Vol. 25, No. 17. pp. 3503-3509.
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