Patterns of orthostatic blood pressure changes in patients with orthostatic hypotension

Hung Youl Seok, Yoo Hwan Kim, Hayom Kim, Byung Jo Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background and Purpose The objective of this study was to determine the patterns of blood pressure (BP) changes during the head-up tilt (HUT) test, particularly in terms of its clinical significance for patients with orthostatic hypotension (OH). Methods OH was divided into four categories based on systolic BP changes occurring within the first 10 minutes of the HUT test: sustained orthostatic hypotension (SOH), progressive orthostatic hypotension (POH), orthostatic hypotension with partial recovery (OHPR), and transient orthostatic hypotension (TOH). Results In total, 151 patients were analyzed: 65 with SOH, 38 with POH, 21 with OHPR, and 27 with TOH. POH patients exhibited the greatest reduction in systolic BP after HUT and were also the most likely to develop symptoms requiring early termination of the HUT test (42.1%, p<0.001). Additionally, SOH patients exhibited smaller heart-rate variation with deep breathing values (p=0.003) and Valsalva ratios (p=0.022) compared to POH patients. The sweat volume was greatest in OHPR patients. Conclusions Clinical characteristics, including the findings of autonomic function tests, differed between the OH patient groups. This might reflect differences in the underlying pathophysiologic mechanisms. Determining the patterns of BP changes during the HUT test may facilitate the development of effective management strategies in patients with OH.

Original languageEnglish
Pages (from-to)283-290
Number of pages8
JournalJournal of Clinical Neurology (Korea)
Volume14
Issue number3
DOIs
Publication statusPublished - 2018 Jul 1

Keywords

  • Blood pressure
  • Orthostatic intolerance
  • Tilt table test

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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