PCL microspheres containing magnesium hydroxide for dermal filler with enhanced physicochemical and biological performances

Sang Woo Shin, Yeon Do Jang, Kyoung Won Ko, Eun Young Kang, Jun Hyeok Han, Tarek M. Bedair, Ik Hwan Kim, Tae Il Son, Wooram Park, Dong Keun Han

Research output: Contribution to journalArticle

Abstract

Polymeric microspheres containing magnesium hydroxide (MH) was developed as a functional dermal filler with enhanced physicochemical and biological performances. In this study, polycaprolactone (PCL) and MH microspheres (PCL/MH) were uniformly produced with approximately 50 μm in size through a simple fluidic device. In the PCL/MH composite, MH effectively neutralized the acidic degradation products generated by polymer degradation. In in vitro cell experiments, when MH was treated with acidic decomposition product (i.e., 6-hydroxycaproic acid, HCA), the acidic pH was neutralized to induce wound healing along with inhibition of inflammation and senescence. Furthermore, MH promoted the production of collagen. These results suggest that the PCL/MH microspheres have great potential as a functional dermal filler for skin esthetics and facial plastic surgery.

Original languageEnglish
JournalJournal of Industrial and Engineering Chemistry
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Magnesium Hydroxide
Polycaprolactone
Microspheres
Magnesium
Fillers
Fluidic devices
Degradation
polycaprolactone
Dermal Fillers
Collagen
Surgery
Skin
Polymers
Decomposition
Acids
Composite materials

Keywords

  • Anti-inflammation
  • Anti-senescence
  • Dermal filler
  • Magnesium hydroxide (MH)
  • Polycaprolactone (PCL) microspheres

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

PCL microspheres containing magnesium hydroxide for dermal filler with enhanced physicochemical and biological performances. / Shin, Sang Woo; Jang, Yeon Do; Ko, Kyoung Won; Kang, Eun Young; Han, Jun Hyeok; Bedair, Tarek M.; Kim, Ik Hwan; Son, Tae Il; Park, Wooram; Han, Dong Keun.

In: Journal of Industrial and Engineering Chemistry, 01.01.2019.

Research output: Contribution to journalArticle

Shin, Sang Woo ; Jang, Yeon Do ; Ko, Kyoung Won ; Kang, Eun Young ; Han, Jun Hyeok ; Bedair, Tarek M. ; Kim, Ik Hwan ; Son, Tae Il ; Park, Wooram ; Han, Dong Keun. / PCL microspheres containing magnesium hydroxide for dermal filler with enhanced physicochemical and biological performances. In: Journal of Industrial and Engineering Chemistry. 2019.
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AU - Bedair, Tarek M.

AU - Kim, Ik Hwan

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