PCL microspheres containing magnesium hydroxide for dermal filler with enhanced physicochemical and biological performances

Sang Woo Shin, Yeon Do Jang, Kyoung Won Ko, Eun Young Kang, Jun Hyeok Han, Tarek M. Bedair, Ik Hwan Kim, Tae Il Son, Wooram Park, Dong Keun Han

Research output: Contribution to journalArticle

Abstract

Polymeric microspheres containing magnesium hydroxide (MH) was developed as a functional dermal filler with enhanced physicochemical and biological performances. In this study, polycaprolactone (PCL) and MH microspheres (PCL/MH) were uniformly produced with approximately 50 μm in size through a simple fluidic device. In the PCL/MH composite, MH effectively neutralized the acidic degradation products generated by polymer degradation. In in vitro cell experiments, when MH was treated with acidic decomposition product (i.e., 6-hydroxycaproic acid, HCA), the acidic pH was neutralized to induce wound healing along with inhibition of inflammation and senescence. Furthermore, MH promoted the production of collagen. These results suggest that the PCL/MH microspheres have great potential as a functional dermal filler for skin esthetics and facial plastic surgery.

Original languageEnglish
JournalJournal of Industrial and Engineering Chemistry
DOIs
Publication statusPublished - 2019 Jan 1

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Keywords

  • Anti-inflammation
  • Anti-senescence
  • Dermal filler
  • Magnesium hydroxide (MH)
  • Polycaprolactone (PCL) microspheres

ASJC Scopus subject areas

  • Chemical Engineering(all)

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