Pentraxin 3: A novel and independent prognostic marker in ischemic stroke

Wi Sun Ryu, Chi Kyung Kim, Beom Joon Kim, Chulho Kim, Seung Hoon Lee, Byung Woo Yoon

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Objective: Pentraxin 3 (PTX3) is one of the pattern-recognition receptors related to the initial step of the immune response with C-reactive protein, but the physiologic and pathologic functions are not fully understood. The purpose of the current study was to determine the impact of PTX3 levels on mortality after ischemic stroke. Methods: We consecutively enrolled 376 patients who had ischemic stroke between September 2004 and September 2006. The patients were divided into tertiles according to PTX3 levels. Cox regression analysis was used to determine hazard ratios (HRs) and 95% confidence intervals (CIs) of the PTX3 tertiles for all-cause mortality with adjustment for traditional risk factors and laboratory variables, including C-reactive protein. Results: During the follow-up, 19.4% of the patients were deceased. The median PTX3 levels were higher in the deceased patients (18.0 vs. 6.4. ng/mL, p<0.001). Based on Cox regression analysis, compared with the first tertile of PTX3, the adjusted HRs of the second and third tertiles for all-cause mortality were 1.24 (95% CI, 0.52-2.98) and 2.64 (95% CI, 1.19-5.85), respectively. When the log-transformed levels of PTX3 were incorporated as continuous variables, higher levels of PTX3 were also associated with an increased mortality (increase per log unit; HR, 1.60; 95% CI, 1.19-2.16). Conclusions: We showed that higher levels of PTX3 are independently associated with increased mortality after ischemic stroke. Our results suggest that PTX3 may be used as a new powerful prognostic biomarker in patients with ischemic stroke.

Original languageEnglish
Pages (from-to)581-586
Number of pages6
JournalAtherosclerosis
Volume220
Issue number2
DOIs
Publication statusPublished - 2012 Feb

Keywords

  • Ischemic stroke
  • Mortality
  • Pentraxin 3

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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