Pep-1 peptide-modified liposomal carriers for intracellular delivery of gold nanoparticles

Myung Joo Kang, Sangyeop Lee, Bo Kyun Kim, Jae Yoon Eum, Sang Han Park, Min Hyung Kang, Chil Hwan Oh, Jaebum Choo, Young Wook Choi

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    A Pep-1 peptide-modified liposomal (Pep1-Lipo) carrier system was investigated to increase the intracellular delivery of gold nanoparticles (Au NPs). Au NPs with a mean diameter of 13 nm were successfully encapsulated into the inner aqueous compartment of the novel carrier using an ethanol injection technique, reserving the distinctive optical characteristics of the surface plasmon resonance peak around 530 nm. The Au NP-loaded liposomal carrier was physically characterized as 150-170 nm in size and 45 mV in zeta potential. Dark field microscopic observation demonstrated that in vitro cellular association and/or translocation of the nanoprobes into the cells was increased by Pep1-Lipo carriers compared to bare Au NPs. In conclusion, this novel liposomal formulation is a promising platform for the intracellular delivery of metallic nanoprobes including Au NPs.

    Original languageEnglish
    Pages (from-to)109-112
    Number of pages4
    JournalChemical and Pharmaceutical Bulletin
    Volume59
    Issue number1
    DOIs
    Publication statusPublished - 2011 Jan 1

    Keywords

    • Gold nanoparticle
    • Intracellular delivery
    • Liposome
    • Nanocarrier
    • Pep-1 peptide

    ASJC Scopus subject areas

    • Chemistry(all)
    • Drug Discovery

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