Pep-1 peptide-modified liposomal carriers for intracellular delivery of gold nanoparticles

Myung Joo Kang, Sangyeop Lee, Bo Kyun Kim, Jae Yoon Eum, Sang Han Park, Min Hyung Kang, Chil Hwan Oh, Jaebum Choo, Young Wook Choi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A Pep-1 peptide-modified liposomal (Pep1-Lipo) carrier system was investigated to increase the intracellular delivery of gold nanoparticles (Au NPs). Au NPs with a mean diameter of 13 nm were successfully encapsulated into the inner aqueous compartment of the novel carrier using an ethanol injection technique, reserving the distinctive optical characteristics of the surface plasmon resonance peak around 530 nm. The Au NP-loaded liposomal carrier was physically characterized as 150-170 nm in size and 45 mV in zeta potential. Dark field microscopic observation demonstrated that in vitro cellular association and/or translocation of the nanoprobes into the cells was increased by Pep1-Lipo carriers compared to bare Au NPs. In conclusion, this novel liposomal formulation is a promising platform for the intracellular delivery of metallic nanoprobes including Au NPs.

Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume59
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1

Keywords

  • Gold nanoparticle
  • Intracellular delivery
  • Liposome
  • Nanocarrier
  • Pep-1 peptide

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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  • Cite this

    Kang, M. J., Lee, S., Kim, B. K., Eum, J. Y., Park, S. H., Kang, M. H., Oh, C. H., Choo, J., & Choi, Y. W. (2011). Pep-1 peptide-modified liposomal carriers for intracellular delivery of gold nanoparticles. Chemical and Pharmaceutical Bulletin, 59(1), 109-112. https://doi.org/10.1248/cpb.59.109