Peptides from Anchovy Sauce Induce Apoptosis in a Human Lymphoma Cell (U937) through the Increase of Caspase-3 and -8 Activities

Young Gon Lee, Ji Yeon Kim, Ki Won Lee, Kyoung Heon Kim, Hyong Joo Lee

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35 Citations (Scopus)


Various biological activities of peptides have been found. In this study, the induction of apoptosis in a human lymphoma cell line (U937) by peptide fraction separated from anchovy sauce was studied using biochemical and flow cytometric methods. After U937 was treated with a hydrophobic peptide fraction of the anchovy sauce, a sub-G1 peak, which represents apoptosis, was found in the cell cycle analysis. The apoptosis in the peptide-treated U937 cell was also confirmed by apoptotic DNA fragmentation. Furthermore, an increase of caspase-3 and -8 activities was observed. Our results suggest that the peptide fraction separated from the anchovy sauce may have cancer chemopreventive effects through the induction of apoptosis in cancer cells.

Original languageEnglish
Pages (from-to)399-404
Number of pages6
JournalAnnals of the New York Academy of Sciences
Publication statusPublished - 2003 Dec 1



  • Apoptosis
  • Caspase
  • Fish sauce
  • Lymphoma cell line
  • Peptide

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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