PER2 variation is associated with diurnal preference in a Korean young population

Heon-Jeong Lee, Leen Kim, Seung Gul Kang, Ho-Kyoung Yoon, Jung Eun Choi, Young Min Park, Seog Ju Kim, Daniel F. Kripke

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The PER2 gene has been reported to influence diurnal preference. In this study, we have attempted to characterize the associations between the PER2 gene polymorphisms and diurnal preference in a population of healthy young subjects, controlling for the social and environmental confounding factors. Subjects were 299 students in a college, carefully selected to be mentally and physically healthy. All subjects completed the 13-item composite scale for morningness (CSM). PER2 gene polymorphisms were genotyped by PCR-based methods. Genotype and allele carrier status of a PER2 G3853A polymorphism (rs934945) were associated with CSM scores. Carriers of the 3853G allele showed significantly higher CSM scores (P = 0.004, P = 0.009, and P = 0.001; total, morningness, and activity plan, respectively). There were no significant differences on CSM scores among genotypes and allele status of PER2 rs2304672. This result indicates that rs934945 of PER2 may be associated with diurnal preference in a Korean healthy population.

Original languageEnglish
Pages (from-to)273-277
Number of pages5
JournalBehavior Genetics
Volume41
Issue number2
DOIs
Publication statusPublished - 2011 Mar 1

Fingerprint

young population
Alleles
genetic polymorphism
alleles
allele
polymorphism
Genotype
Population
Genes
carrier state
gene
genotype
genes
college students
Healthy Volunteers
Students
Polymerase Chain Reaction
environmental factors
environmental factor
student

Keywords

  • Diurnal preference
  • Morningness
  • PER2
  • Polymorphism

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics

Cite this

PER2 variation is associated with diurnal preference in a Korean young population. / Lee, Heon-Jeong; Kim, Leen; Kang, Seung Gul; Yoon, Ho-Kyoung; Choi, Jung Eun; Park, Young Min; Kim, Seog Ju; Kripke, Daniel F.

In: Behavior Genetics, Vol. 41, No. 2, 01.03.2011, p. 273-277.

Research output: Contribution to journalArticle

Lee, Heon-Jeong ; Kim, Leen ; Kang, Seung Gul ; Yoon, Ho-Kyoung ; Choi, Jung Eun ; Park, Young Min ; Kim, Seog Ju ; Kripke, Daniel F. / PER2 variation is associated with diurnal preference in a Korean young population. In: Behavior Genetics. 2011 ; Vol. 41, No. 2. pp. 273-277.
@article{33e03076d40849a0bcb986341bad8be7,
title = "PER2 variation is associated with diurnal preference in a Korean young population",
abstract = "The PER2 gene has been reported to influence diurnal preference. In this study, we have attempted to characterize the associations between the PER2 gene polymorphisms and diurnal preference in a population of healthy young subjects, controlling for the social and environmental confounding factors. Subjects were 299 students in a college, carefully selected to be mentally and physically healthy. All subjects completed the 13-item composite scale for morningness (CSM). PER2 gene polymorphisms were genotyped by PCR-based methods. Genotype and allele carrier status of a PER2 G3853A polymorphism (rs934945) were associated with CSM scores. Carriers of the 3853G allele showed significantly higher CSM scores (P = 0.004, P = 0.009, and P = 0.001; total, morningness, and activity plan, respectively). There were no significant differences on CSM scores among genotypes and allele status of PER2 rs2304672. This result indicates that rs934945 of PER2 may be associated with diurnal preference in a Korean healthy population.",
keywords = "Diurnal preference, Morningness, PER2, Polymorphism",
author = "Heon-Jeong Lee and Leen Kim and Kang, {Seung Gul} and Ho-Kyoung Yoon and Choi, {Jung Eun} and Park, {Young Min} and Kim, {Seog Ju} and Kripke, {Daniel F.}",
year = "2011",
month = "3",
day = "1",
doi = "10.1007/s10519-010-9396-3",
language = "English",
volume = "41",
pages = "273--277",
journal = "Behavior Genetics",
issn = "0001-8244",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - PER2 variation is associated with diurnal preference in a Korean young population

AU - Lee, Heon-Jeong

AU - Kim, Leen

AU - Kang, Seung Gul

AU - Yoon, Ho-Kyoung

AU - Choi, Jung Eun

AU - Park, Young Min

AU - Kim, Seog Ju

AU - Kripke, Daniel F.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - The PER2 gene has been reported to influence diurnal preference. In this study, we have attempted to characterize the associations between the PER2 gene polymorphisms and diurnal preference in a population of healthy young subjects, controlling for the social and environmental confounding factors. Subjects were 299 students in a college, carefully selected to be mentally and physically healthy. All subjects completed the 13-item composite scale for morningness (CSM). PER2 gene polymorphisms were genotyped by PCR-based methods. Genotype and allele carrier status of a PER2 G3853A polymorphism (rs934945) were associated with CSM scores. Carriers of the 3853G allele showed significantly higher CSM scores (P = 0.004, P = 0.009, and P = 0.001; total, morningness, and activity plan, respectively). There were no significant differences on CSM scores among genotypes and allele status of PER2 rs2304672. This result indicates that rs934945 of PER2 may be associated with diurnal preference in a Korean healthy population.

AB - The PER2 gene has been reported to influence diurnal preference. In this study, we have attempted to characterize the associations between the PER2 gene polymorphisms and diurnal preference in a population of healthy young subjects, controlling for the social and environmental confounding factors. Subjects were 299 students in a college, carefully selected to be mentally and physically healthy. All subjects completed the 13-item composite scale for morningness (CSM). PER2 gene polymorphisms were genotyped by PCR-based methods. Genotype and allele carrier status of a PER2 G3853A polymorphism (rs934945) were associated with CSM scores. Carriers of the 3853G allele showed significantly higher CSM scores (P = 0.004, P = 0.009, and P = 0.001; total, morningness, and activity plan, respectively). There were no significant differences on CSM scores among genotypes and allele status of PER2 rs2304672. This result indicates that rs934945 of PER2 may be associated with diurnal preference in a Korean healthy population.

KW - Diurnal preference

KW - Morningness

KW - PER2

KW - Polymorphism

UR - http://www.scopus.com/inward/record.url?scp=79952449949&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952449949&partnerID=8YFLogxK

U2 - 10.1007/s10519-010-9396-3

DO - 10.1007/s10519-010-9396-3

M3 - Article

VL - 41

SP - 273

EP - 277

JO - Behavior Genetics

JF - Behavior Genetics

SN - 0001-8244

IS - 2

ER -