PER2 variation is associated with diurnal preference in a Korean young population

Heon Jeong Lee, Leen Kim, Seung Gul Kang, Ho Kyoung Yoon, Jung Eun Choi, Young Min Park, Seog Ju Kim, Daniel F. Kripke

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26 Citations (Scopus)

Abstract

The PER2 gene has been reported to influence diurnal preference. In this study, we have attempted to characterize the associations between the PER2 gene polymorphisms and diurnal preference in a population of healthy young subjects, controlling for the social and environmental confounding factors. Subjects were 299 students in a college, carefully selected to be mentally and physically healthy. All subjects completed the 13-item composite scale for morningness (CSM). PER2 gene polymorphisms were genotyped by PCR-based methods. Genotype and allele carrier status of a PER2 G3853A polymorphism (rs934945) were associated with CSM scores. Carriers of the 3853G allele showed significantly higher CSM scores (P = 0.004, P = 0.009, and P = 0.001; total, morningness, and activity plan, respectively). There were no significant differences on CSM scores among genotypes and allele status of PER2 rs2304672. This result indicates that rs934945 of PER2 may be associated with diurnal preference in a Korean healthy population.

Original languageEnglish
Pages (from-to)273-277
Number of pages5
JournalBehavior Genetics
Volume41
Issue number2
DOIs
Publication statusPublished - 2011 Mar 1

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Keywords

  • Diurnal preference
  • Morningness
  • PER2
  • Polymorphism

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

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