Percutaneous radiofrequency ablation for symptomatic Uterine leiomyomas

A systematic review and meta-analysis

K. J. Lim, D. Y. Yoon, J. H. Kim, Y. K. Cho, H. J. Kim, Hyeong Sik Ahn, I. M. Ahn

Research output: Contribution to journalReview article

Abstract

Purpose: To evaluate the efficacy and safety of percutaneous radiofrequency ablation (RFA) in the treatment of uterine leiomyomas. Materials and Methods: Medline, Embase, and Cochrane databases were searched through August 2014 for all relevant studies on RFA for uterine leiomyomas. The efficacy and safety of RFA were assessed using the outcome measures of tumor volume, symptom severity score, health-related quality of life (HRQL) score, procedure-related complications, and reintervention. The authors calculated pooled event rates with 95% confidence intervals using random-effects model to assess the effects of RFA. Results: Eight observational studies were identified as eligible for inclusion in this meta-analysis and included 370 patients. All analyzed outcomes showed statistically significant improvements from baseline to final follow-up. Twenty-seven complications were identified and five of them qualified as major complications. Five patients required reintervention after RFA. Conclusions: Percutaneous RFA is an effective and safe treatment for patients with uterine leiomyomas.

Original languageEnglish
Pages (from-to)643-649
Number of pages7
JournalClinical and Experimental Obstetrics and Gynecology
Volume43
Issue number5
DOIs
Publication statusPublished - 2016 Jan 1

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Leiomyoma
Meta-Analysis
Safety
Tumor Burden
Observational Studies
Quality of Life
Outcome Assessment (Health Care)
Databases
Confidence Intervals
Therapeutics

Keywords

  • Leiomyomas
  • Meta-analysis
  • Radiofrequency ablation
  • Uterus

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Percutaneous radiofrequency ablation for symptomatic Uterine leiomyomas : A systematic review and meta-analysis. / Lim, K. J.; Yoon, D. Y.; Kim, J. H.; Cho, Y. K.; Kim, H. J.; Ahn, Hyeong Sik; Ahn, I. M.

In: Clinical and Experimental Obstetrics and Gynecology, Vol. 43, No. 5, 01.01.2016, p. 643-649.

Research output: Contribution to journalReview article

Lim, K. J. ; Yoon, D. Y. ; Kim, J. H. ; Cho, Y. K. ; Kim, H. J. ; Ahn, Hyeong Sik ; Ahn, I. M. / Percutaneous radiofrequency ablation for symptomatic Uterine leiomyomas : A systematic review and meta-analysis. In: Clinical and Experimental Obstetrics and Gynecology. 2016 ; Vol. 43, No. 5. pp. 643-649.
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